We will have to confront a Ship of Theseus paradox (See also Identity over Time for a more thorough discussion).
At what point does the soul leave the body or body leave the soul when the skin has been replaced by radiation-proof cladding and the brain is a silicon-based CPU running neural net algorithms?
What happens to the person's soul when his consciousness is uploaded into the cloud and then copied thousands of times later to be downloaded into a slew of various bodies?
What happens when a person can be a man on Mondays, a woman on Tuesdays, neutered on Wednesdays, and hermaphroditic on the weekends?
Will these highly altered "humans" have souls?
A lot of comedy really surfs on top of deep philosophy.