Not as much as other cities. That nice museum in Philly that Rocky Balboa ran up? Go around the block to the back side and it's a ghetto district where you can get killed. Visit the White House in Wash DC, go two blocks and hit a ghetto district where you can get killed. Visit the tourist district in Seattle and the neighborhood a few blocks away gets dicey. Atlantic City, well try venturing more than a few blocks from the boardwalk. The ghetto is largely confined to the southeastern side of SF far from tourist destinations, and is still relatively safe - worst part is far better than the best part of other cities. The thing about SF is that there is little crime as compared to other cities, or not as much. Go across the bay to Oakland and you'll see a stark difference. You must be referring to the Castro District, and yes that sucks but it's still relatively safe.
Point taken.
But pay top rate for the Saint Francis or the Hilton and walk in the wrong direction and u b in the tenderloin. Ummmm don’t know how to say this but u don’t want to b in the tenderloin.