Posted on 10/24/2022 1:59:21 PM PDT by ConservativeMind
Pancreatitis is inflammation of the pancreas often associated with long-term alcohol consumption. Recurrent attacks of acute pancreatitis results in chronic pancreatitis, causing weight loss, pain, diabetes, and even pancreatic cancer.
Excessive alcohol consumption is associated with 40–70% of pancreatitis cases.
With repeated episodes of binge drinking the pancreas eventually builds up scar tissues with persistent inflammation, weakening its endocrine and exocrine functions needed to digest food and regulate blood sugar levels. This chronic insult to the organ can cause excruciating pain, malnutrition, diabetes, and death.
Accumulating scientific evidence suggests that continued alcohol consumption with established alcoholic pancreatitis instigates irreversible pancreatic damage due to recurrent episodes of acute pancreatitis by fostering a continuous fibro-inflammatory microenvironment within the pancreas.
"Using an established alcoholic pancreatitis mice model, we have addressed two of the major unanswered questions with regards to the pathogenesis of pancreatitis. We've characterized the pancreas-specific signaling pathways in this process and determined if utilizing novel therapeutic agents can attenuate the severity of alcoholic pancreatitis progression, despite continued alcohol triggers" said Siddharth Mehra, Ph.D.
The microbiome has been implicated in gastrointestinal inflammation as a critical mediator of overall gut health. Urolithin A is a natural compound synthesized by gut bacteria from ingested ellagitannins, a class of hydrolyzable tannins found mainly in pomegranate, berries, and nuts. Previous work from the group has shown that Urolithin A is a potent anti-inflammatory agent in several pre-clinical disease models and exhibits anti-tumor activity in gastrointestinal cancers.
"Our studies have demonstrated that Urolithin A is well tolerated and does not elicit any adverse toxic effects at clinically relevant doses in mice," says Dr. Nagathihalli. The FDA recognizes Urolithin A as a "safe dietary supplement."
"We have shown that Urolithin A can help improve the effectiveness of treating alcoholic pancreatitis despite continued alcohol intake," said Dr. Mehra.
(Excerpt) Read more at medicalxpress.com ...
Go ahead. You’re not likely suffering from pancreatitis
Congratulations! 31 years here.
I’m sorry for your loss. My mom died of it in 2006 at 86, but she was never a heavy drinker.
if you don’t mind me asking, how did they diagnose it? What tests did they perform? I’m heading to a gastro doc next week for symptoms similar to comments I read online from people with the same problem.
No doubt about that one! Throw Lot and his daughters in there too
“I’m convinced that alcohol also exasperates cancer risks. I have too many personal examples to quote.”
it’s been definitely proved that alcohol consumption is a factor in breast cancer and throat cancer ...
“I heard he didn’t pay taxes on it either.”
he was allowed to make as many as 200 gallons tax free ...
I am, and know many first nighters.
Sorry for your loss also. A tough way to go, but I was glad I was there for him in the final months.
Yea I’m probably going to get flamed, but , I believe it was Frank Sinatra who said, “ I pity people who don’t drink, it must be terrible to get up in the morning and know that’s the best you’re going to feel all day!”
Yea I’m probably going to get flamed, but , I believe it was Frank Sinatra who said, “ I pity people who don’t drink, it must be terrible to get up in the morning and know that’s the best you’re going to feel all day!”
Alcohol is no ones friend
I have a very interesting story to share, but that’s not going to happen. Why? I don’t believe anyone cares, here or elsewhere. It’s the reason I paused my book.
I will finish someday, but even before the physical conclusions I allude to with my ‘story’ I had already written in my book that anyone seeking to regain their health should abandon alcohol. Period.
Thus, when I read the following of one of the paper’s authors,
>>”We have shown that Urolithin A can help improve the effectiveness of treating alcoholic pancreatitis despite continued alcohol intake,” said Dr. Mehra.
all credibility is lost.
It is an unfortunate circumstance to consider working through, that of an alcoholic not stopping the source of the problem, but that a simple supplement can reverse such a condition while under senseless duress from more drinking, it frankly, amazing.
That means it reverses the condition even faster with those not now drinking.
Dean Martin said that in his act.
WHEN YOU’RE DRINK’N LYRICS DEAN MARTIN
When You’re Drinkin’ Lyrics – based on the song “When You’re Smiling” written in 1889 by Larry Shay, Mark Fisher
Drink to me only, that’s all I ask
And I will drink to you
(Spoken) ‘How long I been on?’
When you’re drinking
When you drinking
The show looks good to you
When you’re drinking, you get stinking
It helps your point of view
But when you’re sober the skies all seem gray
When you’re sober life’s a pain in the-
So keep drinking
That’s what I’m thinking
Cuz’ its what I love to do
You would think this would have been a wakeup call for me - but no. I sobered up for about two weeks but went back to drinking heavily. I finally sobered up for good in March 2010 but only after two additional stints in rehab.
The scary thing about alcohol addiction for me was that I knew what I was doing was killing me, but I could not stop. I wasn't even that concerned about developing pancreatitis again. It was insanity!
I am always willing to give sobriety advice to people who solicit it, but I will not proselytize. However, it is madness to give people something that enables them to continue to drink even after developing alcoholic pancreatitis. If your drinking causes alcoholic pancreatitis, that is, in the words of one of my many friends from AA, "a postcard from God," and you might want to put down the bottle. I just wish I had done it sooner.
My two cents.
Alrighty, then.
What pill for gallbladder disease? etc., etc.
The author outlines a pharmaceutical version of bulimia for alcohol.
Okay, then. Name a single health benefit from drinking alcohol. I’ll wait.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.