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And quercetin and (H)CQ are different enough to tell me that they do not interact with the same targets. Look at those structures. The CQ has a chlorine side group, which is negatively charged, but it contains three nitrogens that are positively charged. Thus, it has an overall positive +2 charge. The addition of the hydroxy group to make HCQ reduces the charge to +1 and makes it more water soluble. On the other hand, the quercetin has five hydroxy groups and two other oxygen atoms, giving it an overall negative charge of -7. Chemically, those negative charges mean that it cannot interact with the same targets that the positively charged (H)CQ interacts with. And if they are not interacting with the same targets, they are not interchangeable.

Nice redirection and/or sleight of hand.

There is no requirement that they work bythe same mechanism. Idiot.