Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Common antibiotic may be helpful in fighting respiratory viral infections (Intranasal Neomycin prevents “viral diseases” (incl. COVID and Type A flu))
Medical Xpress / Yale University / Proceedings of the National Academy of Sciences ^ | April 22, 2024 | Jim Shelton / Tianyang Mao et al

Posted on 04/29/2024 8:46:56 PM PDT by ConservativeMind

A study suggests that a range of respiratory viral infections—including COVID-19 and influenza—may be preventable or treatable with a generic antibiotic that is delivered to the nasal passageway.

A team successfully tested the effectiveness of neomycin, a common antibiotic, to prevent or treat respiratory viral infections in animal models when given to the animals via the nose. The team then found that the same nasal approach—this time applying the over-the-counter ointment Neosporin—also triggers a swift immune response by interferon-stimulated genes (ISGs) in the noses of healthy humans.

"This is an exciting finding, that a cheap over-the-counter antibiotic ointment can stimulate the human body to activate an antiviral response," said Iwasaki.

"Our work supports both preventative and therapeutic actions of neomycin against viral diseases in animal models, and shows effective blocking of infection and transmission," said Iwasaki.

Currently, most therapies used to fight respiratory viral infections—including antivirals, monoclonal antibodies, and convalescent plasma therapy—are delivered intravenously or orally. They focus on stopping the progression of existing infections.

A nasal-centered therapy has a much better chance of stopping infections before they can spread to the lower respiratory tract and cause severe diseases, the researchers said.

The researchers found that mice treated intranasally with neomycin showed a robust ISG line of defense against both SARS-CoV-2 and a highly virulent strain of influenza A virus. The researchers also found that an intranasal treatment of neomycin strongly mitigated contact transmission of SARS-CoV-2 in hamsters.

In healthy humans, intranasal application of Neosporin (containing neomycin) also initiated a strong expression of ISGs in a subset of volunteers, the researchers said.

"Our findings suggest that we might be able to optimize this cheap and generic antibiotic to prevent viral diseases and their spread," Iwasaki said. "This approach, because it is host-directed, should work no matter what the virus is."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: antibiotic; covid; intranasal; intranasalneomycin; neomycin; neosporin; pulmonary; respiratory; respiratoryinfection; respiratoryviral; typeaflu; viraldiseases; viralinfections
We all know that antibiotics can’t do anything but be an antibiotic, right? Wrong.

The CDC and the CDC shills will surely slam this finding as “unscientific and dangerous.”

1 posted on 04/29/2024 8:46:56 PM PDT by ConservativeMind
[ Post Reply | Private Reply | View Replies]

To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 04/29/2024 8:47:36 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Ah, helping to increase the spread of antibiotic resistant bacteria! Awesome!

Some respiratory viruses do increase the risk of bacterial pneumonia. In these cases, it is appropriate to take antibiotics. But I wouldn’t start reaching for the antibiotics for a viral infection based on a single study in mice. Let’s get the robust primate and then human studies done before we start routinely using neomycin for virus infections.


3 posted on 04/29/2024 8:54:31 PM PDT by exDemMom (Dr. exDemMom, infectious disease and vaccines research specialist.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind
I'm not getting how exactly the Neosporin is supposed to be applied to the nose. With a Q-Tip? How far up? How much?
4 posted on 04/29/2024 8:57:44 PM PDT by Carry_Okie (The tree of liberty needs a rope.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: exDemMom
Robust studies, which would really only be helpful after a Cochrane-type meta study, will take at least 10 - 20 years, and having had a lot more studies for that review.

I am fine with using cutting edge, harmless interventions.

You are fine with the deaths for 10 - 20 years, until then.

5 posted on 04/29/2024 9:12:24 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom

Why not? The clot shots got pushed without the usual ten years worth of trials.

Dingbat.


6 posted on 04/29/2024 9:14:59 PM PDT by grey_whiskers ( The opinions are solely those of the author and are subject to change without notice.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom
This activity has nothing to do with any bacteria, exDemMom.

From the write up:

“…triggers a swift immune response by interferon-stimulated genes (ISGs) in the noses of healthy humans.“

It encouraged an immune reaction that then fights viruses, while doing nothing to bacteria.

7 posted on 04/29/2024 9:15:22 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom
But I wouldn’t start reaching for the antibiotics for a viral infection based on a single study in mice.

I'm not going to sit back and do nothing while my pet mouse is dying from pneumonia. I take my owner duties seriously and Ben will get the best care money can buy.

8 posted on 04/29/2024 9:21:49 PM PDT by BipolarBob (Dementia ain't just a river in Egypt. )
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom; BipolarBob

Folks, they checked out the response in humans, too.

Neither of you read the write up.


9 posted on 04/29/2024 9:26:33 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom

start with a distilled water/salt wash up the nose


10 posted on 04/29/2024 9:33:50 PM PDT by magna carta
[ Post Reply | Private Reply | To 3 | View Replies]

To: ConservativeMind

There have been lots of articles since 2020 on the use of nasal sprays to prevent respiratory illness. I’ve used nasal povidone iodine and others such and First Defence and ImmuneMist.

I let my guard down and stopped using the sprays. I got COVID on a cruise summer of 2022 and second time about 5 weeks ago.


11 posted on 04/29/2024 10:33:16 PM PDT by ProtectOurFreedom (“When exposing a crime is treated like a crime, you are being ruled by criminals” – Edward Snowden)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

It’s too cheap to be approved by these a$$clowns for use, same as with COVID and Ivermectin.
There’s no money in a cheap cure. The big bucks are in bio-engineered mRNA ‘vaccines’ and long term medication cycles.

Follow the money. Always.


12 posted on 04/30/2024 4:45:25 AM PDT by PubliusMM (RKBA; a matter of fact, not opinion. The Dhimmicraps are ALL Traitors. All of them.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

13 posted on 04/30/2024 5:10:40 AM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
[ Post Reply | Private Reply | To 2 | View Replies]

To: ConservativeMind
Some backround...

Neomycin

And a paper from this year...

Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract

And from a couple of years ago...

Antiviral effects of azithromycin: A narrative review

Hmmmmm....

14 posted on 04/30/2024 5:18:02 AM PDT by mewzilla (Never give up; never surrender!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: little jeremiah

P


15 posted on 04/30/2024 5:24:57 AM PDT by thinden (buckle up ....)
[ Post Reply | Private Reply | To 3 | View Replies]

To: exDemMom

So - because some folks are too stupid to take a full course of antibiotics, nobody should be able to benefit from proper use?


16 posted on 04/30/2024 5:29:37 AM PDT by trebb (So many fools - so little time...)
[ Post Reply | Private Reply | To 3 | View Replies]

To: ConservativeMind
Neither of you read the write up.

Maybe I didn't but there's no way you prove that by what I posted.

Some of us here keep tradition.

17 posted on 04/30/2024 6:34:04 AM PDT by BipolarBob (Dementia ain't just a river in Egypt. )
[ Post Reply | Private Reply | To 9 | View Replies]

To: mewzilla

That middle link is this study.


18 posted on 04/30/2024 8:03:48 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 14 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson