Posted on 06/08/2019 10:42:55 PM PDT by Rabin
Prostaglandin, a potent bone-resorbing agent, is synthesized in osteoblast-like cells. Since vitamin K reportedly plays an important role in (viscosity, clotting &) bone metabolism, we investigated the effects of vitamin K2 (menatetrenone) on PGE2 production by human osteoblast-like periosteal cells. In cells incubated with menatetrenone (1 microgram/mL = 2.25 x 10(-6) M) for 2 days, PGE2 production was reduced to 50% of that in untreated control cells. In one of these menatetrenone at doses of 0.5-10 micrograms/mL dose dependently inhibited the calcium ionophore A23187-induced release of arachidonic acid (AA) from membrane phospholipids, and in the other the conversion of AA to PG was inhibited, as evidenced by the PG-synthesizing activity in the homogenates of menatetrenone-treated cells with AA being lower than that in untreated cells. The inhibitory effect was almost identical to that for PG production. This study shows that menatetrenone inhibited PGE2 release from cells by inhibiting both PG production steps, AA release from the membrane and PG synthesizing activity with AA. Inhibition of PGE2 production by menatetrenone might be important in improving bone metabolism.
(Excerpt) Read more at ncbi.nlm.nih.gov ...
Rab.
There’s always Natto.
What’s it mean?
This article should eschew obfuscation and say what it means in clear english. I read it and it says nothing except obscure jargon except maybe to experts in this medical area. Is this a cure for toe fungus?
“What’s it mean?”
This is what’s cool about real science.
It means exactly what is says:
“This study shows that menatetrenone inhibited PGE2 release from cells by inhibiting both PG production steps, AA release from the membrane and PG synthesizing activity with AA.”
And then it does make a statement of what it could do - and note the word might:
“Inhibition of PGE2 production by menatetrenone might be important in improving bone metabolism.”
You’re 100% wrong.
It’s very straightforward and direct and simple.
I think it depends if this is you subject, you know.
I’m with the other guy, to me it is a huge amount of babble.
But it’s not my subject.
What’s your subject?
It is not babble at all.
bump
Do I want prostaglandin H synthase inhibited in my osteoblast-like cells?
Roger, got it. The problem is that I went to government schools, so can you translate it for me please?
Vit K plays a role in bone health.
What it doesn't say, which is VERY IMPORTANT is that Vit K blocks the action of certain blood thinners which could kill people who need to take them. A little information is a dangerous thing!
It’s all Greek to me. Oops. Hope I didn’t offend anyone.
You are absolutely correct. There is always an upside and a downside to everything we try to put out of balance.
Aspirin?
I knew that. Now tell me something new.
I just want to know what will increase metabolism and decrease the desire for for food for instant gratification.
I knew it!
Always take your D3 vitamins with K2.
This is an October 1993 journal article.
That’s over 25 years ago.... very old news in medical research. I normally try to cut off at 5 years old as the volume of new research information is great.
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