I know that decades ago, one had to have a blood-test prior to getting married to make sure than the couple were not related although they coined it as testing for STD’s. A county official told me that was the actual reason for blood tests, although she might have been joking.
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I first married in 1962 in Texas, at age 19. Blood tests were required then to ensure no close relationship. There was no info about HIV back then.
In 1962 genetic testing had not yet been developed.