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Cannabis may become 'the aspirin of the 21st century'
UK Independent ^ | Jeremy Laurance

Posted on 04/19/2003 3:26:12 PM PDT by Sir Gawain

Cannabis may become 'the aspirin of the 21st century'

By Jeremy Laurance, Health Editor

19 April 2003

Cannabis, the third most popular recreational drug after alcohol and tobacco, could win a new role as the aspirin of the 21st century, with growing evidence that its compounds may protect the brain against the damaging effects of ageing.

Although the drug distorts perception and affects short-term memory, it may also help prevent degenerative diseases such as Alzheimer's, Parkinson's, Huntingdon's and motor neurone diseases. Scientists at the Institute of Neurology in Queens Square, London, say the "huge potential" of cannabis compounds is emerging, as understanding of its biological and pharmacological properties improves.

Professor Alan Thompson and his colleagues wrote in Lancet Neurology: "Basic research is discovering interesting members of this family of compounds that have previously unknown qualities, the most notable of which is the capacity for neuroprotection."

The results of two trials in patients with multiple sclerosis are expected this summer and the first cannabis-based medicines are being considered for licensing. None of them will have the psychoactive properties of the raw drug when smoked or ingested.

Professor Thompson's team says: "Even if the results of these studies are not as positive as many expect them to be, that we are only just beginning to appreciate the huge therapeutic potential of this family of compounds is clear."

Cannabis was thought to affect the cells like alcohol by seeping through the cell membrane. But in 1990 the first cannabinoid receptor was found, which revolutionised the study of cannabinoid biology. The discovery revealed an endogenous system of cannabinoid receptors, similar to the opioid system, to which the drug bound when it was ingested. Just as endorphins are the body's natural equivalent of heroin, a fatty acid called anandamide (Sanskrit for "inner bliss") is the natural equivalent of cannabis.

The natural system of cannabinoid receptors plays a role in maintaining the balance of chemicals in the brain which regulate the rate at which neurons fire. By altering this system, scientists believe it may be possible to slow or prevent the process of brain decay. David Baker, lead author of the Lancet review and senior lecturer at the Institute of Neurology, said: "Alzheimer's disease is the result of very slow degeneration caused by the death of nerve cells. We probably don't see symptoms until 30 to 40 per cent of the nerve cells have died. Something regulates this decay and if we could slow it by even a small fraction we might delay by a decade the point where someone loses their memory."

But cannabis is a double-edged sword, with potentially damaging side effects. "It may be possible to develop drugs that allow selective targeting of different areas of the brain and spinal cord and there may be a way of limiting the negative effects," Dr Baker said.

A study by Dr Baker and colleagues, in which the natural system of cannabinoid receptors was removed in mice, showed that the rate of nerve loss was increased, indicating its role in preserving brain function. The study, which has been accepted for publication in a medical journal, "really clinches the argument", Dr Baker said.

He added: "Cannabis has gone from the drawing board into trials in record time, largely because of patient pressure. Hopefully it will work and be acceptably safe."


TOPICS: Heated Discussion
KEYWORDS: addiction; wodlist
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1 posted on 04/19/2003 3:26:12 PM PDT by Sir Gawain
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To: Wolfie
-
2 posted on 04/19/2003 3:26:32 PM PDT by Sir Gawain
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To: Sir Gawain
with growing evidence that its compounds may protect the brain against the damaging effects of ageing.

There's already overwhelming evidence that it prevents the brain from maturing.

3 posted on 04/19/2003 3:29:10 PM PDT by Willie Green (Go Pat Go!!!)
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To: *Wod_list
Ping
4 posted on 04/19/2003 3:29:32 PM PDT by Fraulein
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To: Sir Gawain
"Smoke two joints in the morning. Smoke two joints at night. Smoke two joints in the afternoon, and then I smoke two more."
5 posted on 04/19/2003 3:30:17 PM PDT by numberonepal
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To: Sir Gawain
So is this guy's lab a legit military target in the War on Drugs?
6 posted on 04/19/2003 3:33:53 PM PDT by Yeti
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To: Sir Gawain
Oh wow, man.
7 posted on 04/19/2003 3:33:54 PM PDT by Jeff Chandler (This tagline has been banned.)
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To: Sir Gawain; Boot Hill
Huh?? What do ya think of this??!!??
8 posted on 04/19/2003 3:35:12 PM PDT by sit-rep
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To: Willie Green
There's already overwhelming evidence that it prevents the brain from maturing.

When smoked before maturity. After one has achieved maturity, becoming a real one (as opposed to a legal one), anti-aging becomes rather more important.
9 posted on 04/19/2003 3:35:33 PM PDT by Xenalyte (I may not agree with your bumper sticker, but I'll defend to the death your right to stick it)
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To: numberonepal
Smoke two joints in the morning. Smoke two joints at night. Smoke two joints in the afternoon, and then I smoke two more."

I think you mixed up 2 verses...maybe you should cut your morning dose down to just one joint, and see if that helps.

10 posted on 04/19/2003 3:36:24 PM PDT by Yeti
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To: Sir Gawain; -YYZ-; Atomic Vomit; babble-on; Bacon Man; Bandolier; Dakmar; Delbert; FormerLurker; ...
May I be the first to say WOOHOO!
11 posted on 04/19/2003 3:36:47 PM PDT by Xenalyte (I may not agree with your bumper sticker, but I'll defend to the death your right to stick it)
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To: Sir Gawain
This just in: Amanita phalloides predicted to become the Tuber melanosporum of the Twenty-first Century!
12 posted on 04/19/2003 3:38:56 PM PDT by Illbay
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To: sit-rep; Sir Gawain
HAH! Sir Gawain posted it!

Man, get into rehab!
13 posted on 04/19/2003 3:39:59 PM PDT by Illbay
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To: Yeti
I get up in the morning and I smoke two joints. I smoke two, two ... big FAT joints.
14 posted on 04/19/2003 3:40:48 PM PDT by numberonepal
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To: Illbay
I think mildew is going to become the asbestos of the 21st century.
15 posted on 04/19/2003 3:41:30 PM PDT by Yeti
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To: numberonepal
... big FAT joints.

mmmm...hm.

Hog legs.

16 posted on 04/19/2003 3:44:08 PM PDT by Yeti
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To: Xenalyte
This is reminiscent of the "science" of the 1930s that "proved" that cigarette smoking strengthened the lungs.

Heroin had great claims made about it, too. It was named "heroin" for its "heroic" qualities.

And, of course, cocaine is the wunderdrug of all wunderdrugs for restoring strength, endurance, and clarity of thought.

Laetrile would right up there, too, if it only made people high as well as curing their cancer.

17 posted on 04/19/2003 3:44:11 PM PDT by Kevin Curry
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To: numberonepal
Or maybe I should say : "Hillary-ankles"
18 posted on 04/19/2003 3:45:24 PM PDT by Yeti
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To: Kevin Curry
Cannabis, the third most popular recreational drug after alcohol and tobacco, could win a new role as the aspirin of the 21st century, with growing evidence that its compounds may protect the brain against the damaging effects of ageing.>>>

Yes, it keeps you permanently 14 years old.

Speaking bluntly. (Ba DUM bump.)
19 posted on 04/19/2003 3:46:17 PM PDT by homeagain balkansvet
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To: numberonepal
mmm donuts ... er .. mmm trichomes ..
20 posted on 04/19/2003 3:46:51 PM PDT by Gorons
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To: Xenalyte
you might not age but you won't remember anything and OY the munchies!
21 posted on 04/19/2003 3:48:22 PM PDT by pamibach
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To: Gorons
Wow, I can smell that from here.
22 posted on 04/19/2003 3:48:26 PM PDT by Yeti
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To: Sir Gawain; Wolfie
Although the drug distorts perception and affects short-term memory...

If the Liberteen docs can only find a way to get past this, they're home free.

Maybe users forget all about the Alzheimer's, Parkinson's, Huntingdon's and motor neurone diseases - eh?

23 posted on 04/19/2003 3:53:00 PM PDT by Libloather (And it STILL isn’t safe enough to vote DemocRAT…)
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To: numberonepal
I smoke two, two ... big FAT joints.

Wouldn't that be four joints?

(Ya see, two and two equals four...)

24 posted on 04/19/2003 3:56:26 PM PDT by Libloather (And it STILL isn’t safe enough to vote DemocRAT…)
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To: Yeti
Yeah,

Some of my favorite sites for pix is:

http://www.overgrow.com/

and

http://www.yahooka.com/

and

http://www.cannabisculture.com/

and the best overall site for pro-marijuana culture is:

http://www.pot-tv.net/
25 posted on 04/19/2003 4:00:37 PM PDT by Gorons
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To: Gorons
pot-tv?
26 posted on 04/19/2003 4:04:06 PM PDT by Yeti
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To: Gorons

27 posted on 04/19/2003 4:04:28 PM PDT by ALS
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To: Yeti
Yeah, Pot-TV rules, and stuff. :)
28 posted on 04/19/2003 4:05:57 PM PDT by Gorons
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To: ALS
nice poster ..... kind of explains Professor Sprout's appearance as well.
29 posted on 04/19/2003 4:07:01 PM PDT by Centurion2000 (We are crushing our enemies, seeing him driven before us and hearing the lamentations of the liberal)
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To: Sir Gawain
"...it may also help prevent degenerative diseases such as Alzheimer's

from personal experience, it may be that if one is constantly stoned, one cannot tell when one develops Alzheimer's...what were we talking about? Who's gonna order the pizza?

30 posted on 04/19/2003 4:12:11 PM PDT by fourdeuce82d
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To: ALS
Wha?

More evidence of the ties between the Libertarian Party and pagan forces working together to corrupt our youth.

I shoud be shocked, but I'm not.

31 posted on 04/19/2003 4:13:38 PM PDT by Yeti
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To: Willie Green
There's already overwhelming evidence that it prevents the brain from maturing.

Myth. Junk science, exploded completely in four chapters of Marijuana Myths/Marijuana Facts by Lynn Zimmer, Ph.D and John P. Morgan, M.D., including twelve pages of references to studies on that precise point.

32 posted on 04/19/2003 4:13:41 PM PDT by William Terrell (People can exist without government but government can't exist without people.)
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To: Illbay
Man, get into rehab!

I went to re-hab while I was the Navy. The officers on my boat liked me so they offered me re-hab instead of a medical discharge due to the quantity I was found with.

While at re-hab, I had to drive off base to a Hospital to get some work done on a foot. My escort, an E-6 from the re-hab center was a real nice guy...so I thought. After having my foot taken care of, I came out and got back into the van. Since he was black, I thought I would be hip and use his venacular describing the good looking women in the Hospital... 'Man, there is some good lookin' hoes in there...'

Well, the next day, every woman in my group at the "Q" given by my "Therapist", lambasted me for considering women "Hoes". The counselor told me that was the reason I do drugs(weed) is because of my lack of respect for women...

I was 18 years old. I sat back in my chair and said to her, in front of the rest of the class, "You may not understand this, but you just shot this entire month long session's credibilty with that novice diagnosis." She looked at me and forced herself to change the subject.

After class she apologized to me which tore the bottom out of what ever was left of the program's credibilty.

People do not need re-hab. They need focus. Re-hab is a money drain...

33 posted on 04/19/2003 4:13:41 PM PDT by sit-rep
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To: sit-rep
Actually, I agree with you.

My sister, the dope-head, can do rehab with her eyes closed, after four or five times through it.
34 posted on 04/19/2003 4:15:16 PM PDT by Illbay
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To: sit-rep
What do ya think of this??!!??

Think of what, dude?

35 posted on 04/19/2003 4:15:42 PM PDT by freedumb2003 (Peace through Strength)
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To: Sir Gawain
This arguement is not about finding beneficial drugs based on cannibis plants and made into pill form, this arguement is about making smoking pot legal and that is obvious when you consider the goals of the people behind all this and their supporters.

The only positive use for cannibis is for some cases of glaucoma and anti-nausea, and there are already drugs that take care of that and are much cheaper.
36 posted on 04/19/2003 4:15:54 PM PDT by RaceBannon
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To: Sir Gawain
Although the drug distorts perception and affects short-term memory

THAT explains a lot ...

Anybody want to argue on behalf of un-supervised, non-prescription "self-administration" of such 'compounds'?

37 posted on 04/19/2003 4:16:02 PM PDT by _Jim (x)
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To: Gorons
mmmmmmmmmmmmmmmmmmmmmmm
38 posted on 04/19/2003 4:17:29 PM PDT by Delta 21 (GOD....Guns.....& Guts -- It takes all three to be FREE)
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To: Xenalyte

I hear it makes you incoherent too..

39 posted on 04/19/2003 4:19:50 PM PDT by Jhoffa_ (It's called "adoption" Perhaps you've heard of it?)
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To: freedumb2003
since you're are the second person to invite yourself into a ping to one person, I'll share it with you...but you're the last one!

I know Boot Hill well, and I know he is a WOD/anti-drug kinda guy. I am more or less neutral on this subject for my own reasons. "What do you think of this?" was meant as a trigger to get him going... that's all...

There. Aren't you glad you asked?

40 posted on 04/19/2003 4:22:00 PM PDT by sit-rep
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To: sit-rep
There. Aren't you glad you asked?

Hey, it was lying out there for all the world to see and upon to comment.

There's always FReeper mail to keep these things private.

I thought my joke was pretty funny, but these things are relative.

I am a "declare surrender on the WOD, it is a waste of time and $$$" kinda person myelf, not that you asked, but since you want to limit the thread to only those you ping, I wanted to qualify myself.

41 posted on 04/19/2003 4:27:12 PM PDT by freedumb2003 (Peace through Strength)
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To: RaceBannon
In the minds of fanatical potheads (such as they are), smoking marijuana is not merely a way to relax or but a veritable religious experience and philosophy of life in and of itself.

To hear them, one would think that no more pressing issue existed, nor greater good could be achieved, than to legalize marijuana and smoke all day.
42 posted on 04/19/2003 4:27:26 PM PDT by Loyalist ("Of all the crosses I had to bear, the heaviest of all was the Cross of Lorraine."--Churchill)
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To: freedumb2003
lol... ya okay babe...you're in!
43 posted on 04/19/2003 4:28:29 PM PDT by sit-rep
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To: William Terrell
Myth. Junk science, exploded completely in four chapters of Marijuana Myths/Marijuana Facts by Lynn Zimmer, Ph.D and John P. Morgan, M.D., including twelve pages of references to studies on that precise point.

The reference you site is a book and not a medical journal. Is Zimmer and Morgan's work on this subject published in any medical journal?

44 posted on 04/19/2003 4:34:57 PM PDT by FreeReign (V5.0 Enterprise Edition)
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To: Sir Gawain
Aww shucks, you bump me first? Geez, I'm gettin' all weepy.

But seriously, this is NO suprise to anyone following British research of the last ten years. They have been making great strides un-encumbered by U.S. style Prohibitionism.

45 posted on 04/19/2003 4:36:58 PM PDT by Wolfie
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To: William Terrell
exploded completely in four chapters of Marijuana Myths/Marijuana Facts by Lynn Zimmer, Ph.D and John P. Morgan, M.D.

Oh, I forgot about that.
It was on the New York Times bestseller list for umpteen months, wasn't it??? </sarcasm>

46 posted on 04/19/2003 4:37:17 PM PDT by Willie Green (Go Pat Go!!!)
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To: ALS
Harry Pothead and the Magical Herb

http://perso.wanadoo.fr/mediapulp/flash/los_primos/primos_1.htm
47 posted on 04/19/2003 4:42:00 PM PDT by The FRugitive
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To: Loyalist
Let me play devils advocate on your last post.

First I am neutral on this subject. No lean either way...

Now, do we want a total ban on MJ? What about the countless adults, who work everyday, pay their taxes and mow their grass, who once or twice a week take a couple hits of a doob befor Fasier comes on, or while another couple are over and you all are playing cards?

I fully understand the need for prohibition, but I also understand that there are a lot of responsible users in the country. They don't "Get High" every minute of the day. They don't "Waste away". Their biggest thorn is the corporate screening. Because of the idiot who burns a joint in the bathroom at work, every employee must be clean...while the white collar goes and has a couple martinis for lunch...

Justa thought...

48 posted on 04/19/2003 4:42:28 PM PDT by sit-rep
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To: Wolfie; Xenalyte
Seriously, GW Pharmaceuticals

You do realize what this means, don't you? Soon, U.S. pharmaceutical companies will find themselves at a competative disadvantage. Which means that in short order, their bought and paid for representatives in Congress will be singing the praises of cannabis-based medicines.

49 posted on 04/19/2003 4:43:54 PM PDT by Wolfie
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To: sit-rep
No offense, but I hire somebody to cut my grass. I smoke it myself, all on my own (well, with a little help from my friends).
50 posted on 04/19/2003 4:46:41 PM PDT by Wolfie
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