It doesn't matter. In fact it is harder to get elected in low population states. You have to win over individual people. you can't just run a 30 sec commercial. the smaller the election the more retail politics you have to do. that is the entire reason we have IA and NH as the first in the nation. so that the POTUS candidates just can't stand off and spend their way to the election. They have to go meet and greet the people and humble themselves to the voters and when you factore in a low population with an area almost half the size of the USA the energy and ability to connect and run a campaign is even bigger.
But hey nice try in trying to demean her accomplishments.
I think it was 100 year since a sitting gov was defeat in a primary race. In either a low or high population state....