Roe v Wade is a good example of where federalism was not given a chance. By discovering the "privacy" element in the Constitution the Supremes deprived each state the option to vote on and have the citizens voice heard. Hence the decades-old struggle to allow citizens to vote on this critical issue. I would not doubt that many blue (Why again are they blue and we are red - that makes no sense) states would vote to approve abortion
in their states. But it would also allow many (most) states to say no. Those that want abortions would be so "inconvenienced" to travel to those states that approved.
Same with pot - hilarious to see the Obama administration attacking California pot dispensaries when the voters approved them. How was this element of our Constitution summarily deleted?