Or, imagine how advanced humans will deal with religion. There was a sci-fi trilogy a few years back by Peter Hamilton called The Reality Dysfunction. In it, there was a group of humans, called Edenists, who had figured out a way to transfer their consciousness, upon death, into a sort of group mind. Effectively, this made them immortal. Doing this got them excommunicated by all of humanity's religions.
I wonder how our current religions will hold up a thousand years from now? Will genetically engineered humans living in habitats built in asteroid fields be able to relate in any way to the story of a Jewish carpenter or an Arabian tribal prophet?