Look at the Smith and Wesson M&P, which does provide for an optional ambidextrous safety. The grip has inter-changable inserts for various hand sizes and is (to me) more ergonomic.. Added bonus is that you are not giving your money to some uppity Euro company.
I have a Smith and Wesson M&P 45 ACP. Mine lacks the manual safety. I overcome this by following the fundamental firearms safety rules (finger off the trigger unless I'm about to shoot, only point at that which you intend to destroy, etc...).
I have one in S&W .40 - a most excellent machine for those shopping.
I have a S&W M&P 357 sig love the gun. I bought it over the glock only because it was more comfortble. Nothing wrong with Glocks though.