If I was being hunted in Detroit I would still prefer the .22LR. ;-)
Take it from someone who once faced six armed men with only a 22 - you'll be wishing you had a bigger gun...
I have two rugers 22s; what a great pistol...
I'm from Detroit. That would be a mistake. Trust me, you want a major caliber. .357 would be OK. .44 Special, .45 ACP, .45 Colt or 10mm would be better.
Maybe we need to review Detroit Basics 101?