She’d get her rear end kicked. It’s no contest, the same for male against female contest among pros whatever the sport. A few years ago when Martina Navratilova was wasting everyone on the women’s tour (on the tennis court), John McEnroe said that on his worst day, he’d whip Martina love and love in a three set match.
You’re assuming Serena is 100% female. And I’m not being sarcastic or exaggerating when I say that. I’m convinced that she’s been on some form of testosterone therapy for years. It’s not just her physique either. Her conduct, attitude, demeanor and mannerisms off the court all point toward something not being right about her femininity.