Actually, I take that back. There is a third way, but not one Americans would go for.
Government takes all confiscated drugs, and possibly additional ones it produces, poisons them and releases them back into the market.
Users randomly die. Eventually all users will either be poisoned or decide using is too dangerous and will stop.
But this is just another, somewhat more drastic, method of attacking the root of the problem, which is consumption. Doing this will work, attacking distribution will never work.
NOW, that would work to kill the “desire”...except for the truly demented....maybe even starting a rumor that the drugs coming in are “tainted” with poison right now by some legitimate group could help. If drugs are “regulated” by the government we’d just have “regulation problems” and an underground market for NON-regulated drugs....it’s never ending...it’s a culture problem.
Cool - nonjudicial mass executions! Screw the Founding Fathers, let's emulate today's Third World sh*tholes.