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No...there were no Neanderthals in the Americas. They died out about 10,000 years before the ancestral Amerinds came to North and eventually, South America. Neanderthals mated with ancestral Europeans and ancestral Asians. Recent evidence points to Amerinds having about one-third European genes...SO: that's how the Neanderthal genes got there.

There were never any Neanderthals in Africa, thus Africans never had the chance to interbreed with them.

One would beg to differ.

1. Absence of evidence is not evidence of absence.

“No...there were no Neanderthals in the Americas.”

2. A negative cannot be proven.

Hypothesis: If there were no Neanderthals in Americas, from whence did the 50% gene factor originate?

Asia?

Australia?

Hawaii?

Would there not be 50% factor remaining in Asia somewhere?
[Hairy Ainu?]
Or did the Asian 50% factor die out too, in Asia and left Amerinds orphans on a new continent(s)? or was the 50% diluted by interbreeding in Asia?

3. Or did the Proto-Europeans cross an ice/land/sea/boats bridge from the northern European shores to Americas inbetween Ice Age glacial flows?? [AHA! Did Neanderthals know how to build a boat???]

4. Do Canadian, USA and Greenland eskimos have the 50% gene factor?

well duuhhhhhh

Well, First nation people just gotta know, ya`know

or they just can`t sleep at night not knowing what the hell happened to their 50% way back when...