[SampleMan]

I didn't see what cartridge his pistol was chambered in, but short of artillery, there isn't much that is a guaranteed instant kill to the chest.

Only severing the spinal cord or exploding the brain can ensure an instant kill.

I've shot deer through the chest and had them run 100 yards. Postmortem showed an exploded heart and gelatinized lungs, and I don't think you'll ever beat the destructive power of a .25-06 with any pistol round.

[logic101.net]

I don’t think you’ll ever beat the destructive power of a .25-06 with any pistol round.

.45 cal 230 gr. jacketed black talon hollow point - makes a real mess.