It is theoretically possible, particularly with the element of surprise, but pretty unlikely even then. For her to disable them enough to “win the fight,” she would almost certainly have had to put them into the hospital or possibly kill them. She’d have to attack their most vulnerable points all-out. If things got to a muscle vs. muscle grappling, she’d lose.
For a man of this size and weight to beat up two “huge” guys is unlikely. They’d presumably outweigh him by a factor of 4x to 6x or more. For a women, with little more than half the upper body strength of a man of the same size, it is that much less likely.
For some obscure reason, movies and TV try to convince us that women can compete with men in this arena on a more or less even footing. Just not true, and never will be.
Given equal size and skill, the man will win every time. A woman would have to be MUCH more skilled, and probably lucky too, for her to defeat a larger man in hand to hand. Such women exist, but they’re darn rare.
An intelligent woman who wants to defend herself would carry a gun and spend her time becoming proficient in its use rather than messing about with “self-defense” stuff.
It depends on how they were "huge". If it was two NFL linebackers, then yes she would be in trouble. If it was two out of shape fat slobs, then she probably could put a hurting on them.
We have a winner.
You’ve summed it up about as well as it could be stated.