The issue is whether amendments can be crafted to make violation of the principles of the Constitution more difficult.And also whether the Seventeenth Amendment can be, if not repealed, somehow defanged. My suggestion for the latter would be to link the election of senators to the election of the state government. If the senators were required to be running mates of the governor, there would be at least some connection between the Senate and the state governments.
Another approach would be to have each state legislature nominate two candidates for senator, one by the majority caucus in the state legislature and one by the plurality of the remaining legislators. The latter method would assure each sitting senator would be beholden to the state legislature, and dependent on it for renomination.
I don't believe that to be possible with the country as it is now. The Constitution is being ignored daily in so many ways that the statement "the rule of law is dead in the USA" is no longer an exaggeration, it is a fact.
An amendment would be ignored just as the Constitution and the Bill of Rights are currently ignored and under assault.