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Researchers identify the molecular target of J147...nearing clinical trials...Alzheimer's disease
medicalxpress.com ^ | January 9, 2018 | Salk Institute

Posted on 01/09/2018 12:49:23 PM PST by Red Badger

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To: unlearner
Not to downplay the possibility that Turmeric and and Curry may have significant health benefits, but the average lifespan in rural India is late 60s versus late 70s in the USA.

The calculation has already taken that into account. Freepers never like to read the article/watch the video....

21 posted on 01/09/2018 2:21:12 PM PST by Pelham (all warfare is based on deception)
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To: Red Badger

Will we know it’s working when Minnie Mouse starts looking hot?


22 posted on 01/09/2018 2:43:22 PM PST by sanjuanbob
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To: sanjuanbob

Or Daisy......................


23 posted on 01/09/2018 2:44:53 PM PST by Red Badger (Road Rage lasts 5 minutes. Road Rash lasts 5 months!.....................)
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To: Pelham

“That (life expectancy differences) has already been accounted for in the calculation (for different rates of Alzheimer’s in high-curry consuming India vs. Pennsylvania)”

In that case, it is likely a very dramatic comparison, indicating a role for curcumin in preventing Alzheimer’s.

I don’t want to rain on the powerful support for curcumin found in that comparison (which I believe). Population studies are just so vulnerable to confounding factors. Vegetarianism is the norm in rural Hindu India. Genetic factors could be very distinct between those populations. Other components in curry (or chai tea) might be factors.

In my cursory analysis, I would think that Life expectancy would likely be the major confounding factor (as Alzheimer’s is so correlated to age), and other factors would be relatively much less influential.

The controlled study just published in Nature is much more definitive evidence.


24 posted on 01/09/2018 2:52:48 PM PST by BeauBo
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To: BeauBo

Those are all good points.

The MD who runs NutritionFacts does a pretty good job of only using well designed studies. I don’t think that he tries to oversell the potential of turmeric in this video. Just that it looks promising.


25 posted on 01/09/2018 2:59:01 PM PST by Pelham (all warfare is based on deception)
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To: unlearner
Not to downplay the possibility that Turmeric and and Curry may have significant health benefits, but the average lifespan in rural India is late 60s versus late 70s in the USA.

True, but they are also have through the roof poverty, most of the country doesn't have proper sewage (i.e. feces in their water source) or routine vaccinations.

26 posted on 01/09/2018 3:04:14 PM PST by Lizavetta
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To: Pelham; Lizavetta

“The calculation has already taken that into account. Freepers never like to read the article/watch the video.”

Your link is to a video which cites some research from 2001.

Here is a link to the abstract cited in the video:

http://www.dementia-epidemiology.pitt.edu/IndoUS/IndoUS_ScientificReports/Chandra2001Incidence.pdf

Note the final paragraph of the abstract:

“There are other, possibly inter-related, reasons for the low incidence of AD in the Ballabgarh cohort. Low average life expectancy in India, with fewer persons living into age of risk, might reduce incidence, especially if there is selectively earlier mortality of those at increased risk. Low incidence rates may also suggest the presence of underlying protective factors, or the absence of underlying risk factors...
given the relatively short duration of follow-up in out study, the small number of incident cases, the wide confidence intervals, and our stated concerns about potential under-reporting of mild disability, we urge caution in the interpretation and generalization of our results.”

Like I said... the evidence from comparing people in India with Americans does not strongly support Turmeric and Curry being preventative of dementia.

However, it is certainly possible. I take Turmeric and Curcumin daily because these have many beneficial properties. I also consume a significant amount of coconut oil. I lost a close family member to dementia and am concerned that I will be at risk in my later years. I don’t know if these lifestyle choices will prevent or minimize my risk, but I do not think they will hurt.

Thanks for sharing.


27 posted on 01/09/2018 4:19:17 PM PST by unlearner (You will never come to know that which you do not know until you first know that you do not know it.)
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To: Lizavetta; unlearner

and maybe that is their secret....

https://tinyurl.com/ybyk2tau


28 posted on 01/09/2018 4:27:01 PM PST by Pelham (all warfare is based on deception)
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To: Pelham; Lizavetta

“maybe that is their secret”

I think I’ll stick with Turmeric.

Even absent of a scientific study, I’m pretty confident that poor sanitation does nothing to prevent dementia.


29 posted on 01/09/2018 4:44:01 PM PST by unlearner (You will never come to know that which you do not know until you first know that you do not know it.)
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To: Red Badger

So what am I supposed to do with all this J146?


30 posted on 01/09/2018 4:45:28 PM PST by Libloather (Trivial Pursuit question - name the first female to lose TWO presidential elections!)
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To: Red Badger

Glad I take this already.

https://www.amazon.com/Gaia-Herbs-Turmeric-Strength-Phyto-Capsules/dp/B00F1J8K4I/ref=sr_1_3_a_it?ie=UTF8&qid=1515545341&sr=8-3&keywords=gaia%2Bturmeric%2Bsupreme&th=1

I’d like to see those young looking worms.


31 posted on 01/09/2018 4:49:02 PM PST by Yaelle
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To: unlearner; Pelham
I was referring to lower lifespan, not less dementia.

Although the lower dementia might be, as you say, because of lower lifespan, as dementia is related to aging.

I'm inclined to believe their diet i.e. low fat, less animal products, more minerals from spices, no processed garbage, chemical-laced foods, no soda, etc. only increases one's lifespan and general health.

I'm a firm believer that cardio exercise and healthy (i.e. real) food is a big deterrent to dementia and a host of other health ailments. But that's just me. :)

32 posted on 01/09/2018 5:10:43 PM PST by Lizavetta
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To: reed13

keeper


33 posted on 01/09/2018 7:32:02 PM PST by reed13k
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To: Libloather

Trade it in.....................


34 posted on 01/10/2018 6:10:47 AM PST by Red Badger (Road Rage lasts 5 minutes. Road Rash lasts 5 months!.....................)
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To: glock rocks

Thanks for the referral.


35 posted on 01/13/2018 8:57:04 AM PST by Excellence (Marine mom since April 11, 2014)
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To: BeauBo

I’m going to look into this, thanks.


36 posted on 01/13/2018 8:59:37 AM PST by Excellence (Marine mom since April 11, 2014)
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To: Excellence

You’re welcome. Their manufacturing process makes the curcumin much more bioavailable. I’m not fighting cancer, so I don’t need a 1000 mg capsule. It’s described at the link ...


37 posted on 01/13/2018 7:49:18 PM PST by glock rocks (... so much win!)
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