When I think of running, I think of Jim Fixx https://en.wikipedia.org/wiki/Jim_Fixx
The money quote:
“Cooper concluded that Fixx was genetically predisposed - his father died of a heart attack at 43 after a previous one at 35, and Fixx himself had a congenitally enlarged heart - and had an unhealthy life: Fixx was a heavy smoker before beginning running at age 36, had a stressful occupation, had undergone a second divorce, and his weight before he took up running had ballooned to 214 pounds (97 kg).[6] Medical opinion continues to uphold the link between moderate exercise and longevity.[7]”