Drug addiction.
Alcohol addiction.
Mental Health Illness and other Health Issues.
(Those are the same. one can have a heart attack, stroke, cancer or mental breakdown. They are all the same and largely beyond your control)
Being without family or friends.
Destroying any relationship you had with friends and family.
I remember about ten years ago, a hurricane hit the north east and seeing a man, roughly 55 years old, being interviewed going into a storm shelter. Of course he gave the "woe is me" routine, and got sympathetic response from the "reporter".
It struck me, you've lived more than a half a century, and in all this time you are neither able to provide shelter (this was in an upland location in an urban area) for yourself, or have established relationships of any kind that you can turn to in a life endangering situation. No family, no friends, no employer, no church, no neighbors. Demonstrably, everyone who knew this man would rather he risk death than inviting him into their home for one night.
Not having known this fellow, I do feel comfortable in saying with one hundred percent certainty, he is a horrible, horrible person who society would be so much better if the storm sent him to his final reward.