What I know: I use it all the time and it doesn’t seem to cause me any issues. A good friend gets an upset stomach even with enteric coated aspirin, so he doesn’t use it. I think both of us are reasonable.
So many studies are about “association” that I’ve almost given up on “science”, although my degree was in Biology and I loved studying science in the 70s!
And there are so many factors. According to science, most likely the men on the Endurance voyage never should have able to survive.