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Safety of high-dose ivermectin: a systematic review and meta-analysis

Results: The systematic search identified six studies for inclusion, revealing no differences in the number of individuals experiencing adverse events. A descriptive analysis of these clinical trials for a variety of indications showed no difference in the severity of the adverse events between standard (up to 400 μg/kg) and higher doses of ivermectin.

Organ system involvement only showed an increase in ocular events in the higher-dose group in one trial for the treatment of onchocerciasis, all of them transient and mild to moderate in intensity.

[jonrick46]

From study at your link:

“there are not enough data to support a recommendation for its [Ivermectin’s] use in higher-than-approved doses.”

“Ivermectin frenzy: the advocates, anti-vaxxers and telehealth companies driving demand”:

https://www.theguardian.com/world/2021/sep/13/ivermectin-treatment-covid-19-anti-vaxxers-advocates