The Virus that Dare Not Speak Its Name

November, 2021 | aruanan

[aruanan]

The Virus that Dare not Speak Its Name

The most glaringly obvious and the single most unheard thing about the mRNA products (but something that explains virtually all the adverse events, both in kind, degree, and combination) is that each of those products is, at the very least, the functional equivalent of a virus, with a few notable but still very serious distinctions.

I came to this conclusion by considering the nature of the therapeutic vehicles they are using. I had been reading about most of these at least since starting grad school over 25 years ago.

I remember talking with a grad student friend in Immunology about possible ways to target cancer cells. I said that if various cancer cells were found to express specific and unique cell surface proteins simply as a consequence of their derangement/loss of original cellular identity, then compounds targeting those cell surface proteins could be ligated to something deleterious to the cell and the cancerous cell could be taken out with a minimum of damage to other cells, unlike what happens In chemotherapy. He told me people were working on things like that.

Well, shit. Scooped again.

Anyway, since that time I have continued to see reports in one journal or another about work on various methods of targeted delivery of therapeutics at the tissue or cellular level.

***

When You Have a Product that Hasn’t Worked as Expected then Use a Disaster to Repurpose It as Another Kind of Product

What these companies have done, then, in an effort to appear to have made rapid breakthroughs into a brave new world of vaccine technology, is simply to repurpose some technologies they or others had been working on for at least a couple of decades. These technologies were originally intended to make possible targeted delivery of chemo directly to sick cells or to target other kinds of problems, maybe by introducing at the cellular level anti-sense RNA or its equivalent that could bind to mRNA copies of defective genes and mitigate trouble caused by their expression or irreversibly bind to the defective genes themselves and permanently silence them.

So these pharmaceutical companies used still-experimental drug delivery vehicles as cellular-scale cargo trucks to slip some cheaply and easily-made viral RNA into the targeted cells, relying on the well-known fact that ribosomes, the cell’s protein synthesizing machines, are totally promiscuous and indiscriminate.

Oh, wait, did I say targeted cells? There are no targeted cells or, rather, any cell with a plasma membrane is a target of the three products marketed in the US.

To give you an idea of the danger of anything but the cell itself having access to its productive capacity, consider this: when an mRNA molecule bumps into an unoccupied ribosome, the ribosome clamps on and gets busy. For the ribosomes, the minimum necessary condition they require for protein synthesis is an mRNA molecule, regardless of origin, whether produced by its own cell, a pathogen, or a lab. If something looks like mRNA, then it gets treated like mRNA.

The innate immune system, in this respect, is like the ribosome; if something looks to the innate immune system like non-self junk or like a pathogen, then the innate immune system treats it like non-self junk or a pathogen. It either sequesters and disposes of the non-self junk or kills, sequesters, and then disposes of the destroyed pathogen’s debris.

It does, though, at least have the courtesy to alert other cells in the immune system to the presence of illegal alien intruders and give the adaptive immune system something by which to recognize the invaders the next time and prepare for them the kind of welcome they merit—unlike the ribosomes that will do any mRNA regardless of origin like Thai hookers and sailors on shore leave.

***

What You Think Something Will Do or Ought to Do or Should Do Counts for Nothing Compared to What It Actually DOES Do.

Perhaps, like a UK friend initially thought, the execs ultimately responsible for jerry-rigging these molecular drug delivery devices in order to press them into service as vaccines also thought that a “few cells” blowing up from overproduction of a single viral spike protein was a small price to pay for acquired immunity to that protein and the pathogen sporting it.

But everything we have seen to date leads us to believe that from the beginning their vision was of the tunnel variety with them imagining:

1. That all they had to do was to stick some viral mRNA into a cell,

2. That it would automatically produce some viral protein,

3. That the protein would then train the adaptive immune system to make antibodies; and

4. That the end result would be the same as using any other normal vaccine produced for over 100 years.

***

The Invisible Elephant in the Room or “It wasn’t invisible because it couldn’t be seen,
but because seeing it would seriously impede getting something they wanted really bad.”

But events following the roll-out of their products have demonstrated that their fundamental problem, still unsolved because, apparently, it has remained unnoticed by them, lay in looking at everything in terms of what they hoped to get out of their products instead of what their products would do to the system they employed them on and to everything the system was connected to downstream.

And not the immune system, whether innate or adaptive, but the system of the human body. And not just the continued biological life of the individual human, but literally everything it is connected to downstream, that is, everything created by it that depends on it for its own continued existence.

I say this to emphasize that, while it’s okay to mess with Mother Nature, you cannot forget that the outcome will depend entirely on what you do to the system and how the system responds to your actions instead of the way you believe or hope or want or have computer modeled that the system would respond.

In altering their products’ primary mechanism of action from

A. delivering deadly drugs to knock off a limited number of deranged cells that posed a danger to the organism to

B. sneaking viral mRNA or its vectorized RNA precursor into a wide variety of healthy cells doing the cellular equivalent of just standing on the street corner, minding their own business,

those guys appear to have acted as though major portions of innate immune system simply did not exist.

And to compound that set of problems, it appears that the guiding motive among leadership in these companies for adopting this particular strategy of delivering inherently risky products was that they didn’t want to shoulder the risk, the responsibility, and the huge cost of culturing, purifying, and processing the vast quantity of viruses needed to make the initial 5 billion or more doses of a protein-based vaccine (and many times over that for boosters and variant add-ons all using the same primary mechanism of action) over a period time too short to do it and, so, were keen on finding another way.

Perhaps even something like the Congressional Democrats who, failing to put something to a vote for fear of losing the vote, instead agree to deem it as having been passed.

Perhaps the leadership of these companies sensed the expedient of devising something they could deem to be a vaccine because it ostensibly shared enough surface features with traditional vaccines—well, more accurately, because the surface features they chose to talk about appeared in the mind of the general public to share enough similarities with what the general public conceived to be a traditional vaccine and, as a result, something they would uncritically accept AS a vaccine.

Such an urge would appear, if not reasonable, then at least understandable, given the circumstances.

***

An Aladdin’s Cave of Riches and Power Beyond Anyone’s Dreams

No, silly, not the circumstances of a worldwide pandemic of fear socially engineered by means of a generally innocuous common cold virus, its presence not reliably detected by any assay over almost its entire history, its apparent rate of incidence and fatality visible only by wholesale appropriation of whatever respiratory diseases the effects of which are usually attributed to flu each year, its rate of fatality (up until the launch of the vaccines) invisible against yearly overall mortality figures for at least 50 of the past 60 years, its primary and most seriously-affected group being the same group most seriously affected by the 200 respiratory diseases collectively referred to as the “common cold,” the influenza, impaired immune systems, multiple comorbidities, and broken hips.

No, I’m talking about something much more important to these companies that had been given a glimpse through the federal peephole into an Aladdin’s cave of endless wealth along with an ASAP deadline for devising the magic phrase.

The pressure of that combined with

1. their knowledge of the cost and time constraints of existing methods of vaccine production,

2. insane levels of anxiety over getting beaten by the competition in being first to market,

3. the prospect of a stream of more money and control than in their wildest dreams guaranteed by the very same folks who came up with the concept of too big to fail, and

4. being indemnified against actions for any deaths or damages caused by their products,

pretty much guaranteed that no one in that whole set-up was going to have much motivation to refrain from cutting corners, lying, spinning, and doing everything they could to make it appear they were doing everything they could.

And all the while they were trying to come up with something to pass the sniff test, fortunately not too difficult given C19’s alleged impairment of the olfactory sense (and, apparently, ethical sense), they continued doing their part along with all the other politically indemnified enablers to make the threat they used to justify all of it appear more immediately harrowing and horror-inducing than a meteor strike like Chixhulub or whatever their costumed freaks gluing their tits and junk to motorways and public transportation claimed for global warming or the prospect of eternal thrombosed hemorrhoids only fleetingly amenable to treatment by 4 million Scoville rectal cream, while passing off their products as the only way out.

***

But There Was a Major Obstacle Blocking Access to All that Loot

That major obstacle was reality.

Here’s what they were up against because of the very narrow time constraints:

To make a traditional vaccine from viral proteins, they would have had to cultivate viruses in one of three main ways: in chicken eggs, in living animals, or in cell culture.

Say that they were going to culture them in chicken eggs and each egg could supply enough viral antigen for 1,000 doses. For 5 billion doses, they would need 5,000,000 fresh fertilized eggs. Not only that, those eggs would have to have living chicken embryos between 7 to 12 days old. Each egg would first have to be disinfected with an iodine solution. Then the shell would have to be drilled through under sterile conditions with a small drill, also sterile.

After that, the viral inoculate would have to be injected into the correct compartment of the egg. For influenza viruses, that is an injection into either the amniotic or allantoic compartments. For avian adenovirus, it’s the allantoic compartment. Following inoculation with the virus, the eggs have to be incubated for 2 or 3 days at 36C. A successful inoculation is detected by the presence of a dead chick, visible lesions on the chick, or cellular damage. The egg contents are then processed to recover the viruses.

If not chicken egg inoculation, then they could use animals such as suckling mice less than 48 hours old, hamsters, guinea pigs, rabbits, and primates, all screened for health and lack of communicable disease and much more expensive and labor intensive, though you can tell by changes in behavior if the animals have been successfully infected with the virus as well as easily test for the presence of antibodies (1).

One of the easiest methods is cell culture, using specific cell lines known to be best suited for culturing particular viruses.

Each method has advantages and disadvantages.

All require expertise, special conditions, specific methods for isolating and purifying the viral harvest, and then more work to process the viruses into the desired antigens for a usable vaccine.

To produce more than 5 billion doses over the course of a few months by any of these means would have required a significant expenditure in capital costs to create new facilities and train new people to accommodate the production of that many doses within a prohibitively very short window of time. Sometimes a lot can be accomplished more quickly by spending vast sums of money, but the effect of that lies principally in being able to clear away impediments to getting the process under way. More money won’t alter the time the process requires.

Aside from the cost deterrent of going the traditional protein antigen vaccination route, an all-out race to be the first to market would favor whoever used the cheapest possible method to get something out as quickly as possible that could in some way be defined as a vaccine, even if it was wholly unlike anything usually known as a vaccine.

The idea of avoiding the huge demands of time and money required to develop and produce conventional vaccines by adapting to immunization the technology of proprietary drug delivery systems intended for targeting treatment to specific cells and tissues, no doubt occurred to multiple people in all these companies.

***

A Pod of Whales, A Murder of Crows, A Mob of Kangaroos, and A Brainstorming of Bright Guys

I imagine the product development brainstorming sessions probably went a little something like this:

Project manager: “Okay, people. Trump said he wants to come up with a vaccine quickly so he’s cutting red tape. So we need to come up with something fast and beat everybody to market. Ideas?”

Bright Guy 1: “Well, since the bottleneck will be on production after we figure out our vaccine design, maybe we can get a jump on everyone by buying up contracts for all future production of embryonated chicken eggs, since that technology has been used successfully since the 1930s.”

Bright Guy 2: “Yeah, but it’s going to take a shit ton of investment up front not only to buy those contracts but to expand production capacity to meet what looks like is going to be very high demand.”

Bright Guy 3: “And if someone else corners the easier or cheaper means of viral cultivation before we do, then we will always be behind. So get our orders in right now, ASAP?”

Bright Guy 4: “Look, if we do buy all the contracts for embryonated eggs for the next few years and then someone comes up with a faster way to grow and harvest viruses to get the viral protein antigens for the vaccine, then we are going to be totally fucked. No way we can just eat that kind of loss.”

Bright Guy 3: “Or that many eggs. We can’t just sell them because no one will want to crack a couple eggs into a frying pan and see baby birds instead of yolks. And I don’t think you could market them as “high protein eggs” or sell them to the Vietnamese or Philipinnos who love weird-ass shit like that. What about the French?”

Bright Guy 1:“No, they go for stuff like eating live sea urchins. And their birds have to already be on the wing, like the ortolán, then they’ll put a towel over their heads and eat everything but the beak.”

Bright Guy 3: “Wouldn’t the sea urchins get stuck on the way down?”

Bright Guy 2: “Stuck on the way down? What about on the way out? Good roughage, I guess.”

Bright Guy 1:“No, the sea urchins they crack open from the bottom through their little mouth and scoop out the insides with a demitasse spoon like they’re eating yogurt out of a cup or a soft-boiled egg while the little spines are still waving around.”

Bright Guy 3: “So what’s the alternative?”

Bright Guy 1: “I don’t think they could boil them like eggs, though the insides would probably firm up and be okay with a bit of salt.”

Bright Guy 3: “No, numb-nuts. Alternative to culturing viruses in eggs.”

Bright Guy 2: “Cell culture would still be expensive and forget about monkeys or chimps or PETA will be all ape shit over our asses.”

Bright Guy 4: “Look, if we first clearly define our objectives, then we can probably get a better idea about the most efficient means to achieve them. As I see it, our objectives are these:

1. Come up with a vaccine before anyone else does,
2. Beat them all to market,
3. Do it in as cheap a way as possible that requires as little time and effort as possible because time is money and labor is the most expensive part of any business,
4. And still do it all in a way that’s not perceived as the same old thing and that could capture the public’s imagination as something glittering with all the shiny chrome of brand new cutting-edge science.”

Bright Guy 1: “Yeah, but it still has to be a vaccine and doing that still takes a lot of time and money.”

Bright Guy 4: “Well, let’s look at what’s actually involved in the process of using a viral antigen to produce an antibody response against that virus. That could give us an idea. Or maybe we’ll see something between the cracks no one’s noticed before. So what are the basic ingredients and steps that are needed?”

Bright Guy 2: “Well, you need something you can infect with the virus to produce the viruses from which you’ll get the viral proteins to make the antigens that will be put into the vaccine to stick into people to be picked up by the cells of their innate immune system to be presented to the T and B cells of their adaptive immune system to make antibodies against that virus that will protect them from getting infected.”

Bright Guy 3: “Effing brown-noser.”

Bright Guy 1: “Except he got two things wrong. The first is that B cells don’t make antibodies against the virus. They make them against epitopes on the bits and pieces of the viral proteins presented to them by the innate immune system. The antibodies are going to stick to those places on that protein no matter where it is, part of the virus, floating around by itself, or stapled to the back of that embroynated chicken trying to cross the road.”

Bright Guy 3: “And what’s the other thing he got wrong.”

Bright Guy 1: “Oh, yeah. Although you can stimulate the initial production of antibodies either by a vaccine or by being infected, you can’t trigger the subsequent release of those antibodies without either another vaccination with the same antigens or another infection. No infection, no activation of the adaptive immune system by the innate immune system, except by another vaccination.”

Bright Guy 3: “So then what’s the point?”

Bright Guy 2: “So once you inevitably do get infected your combined innate and adaptive responses will take it all out, usually without you even knowing.”

Bright Guy 3: “So you’re saying that what you need is for the innate immune system to find something that’s not supposed to be there and then, by using the proteins left by whacking the virus, it sets in motion a chain of events that REALLY makes sure it won’t happen again.”

Bright Guy 2: “So if all we really need is just the viral proteins, not the viruses at all, then where are we going to get the proteins if not from the viruses?”

Bright Guy 1: “I know they’ve gotten bacteria to make human insulin in some way after they put the human DNA in it. And I think the NIH has the RNA sequences of a lot of different viruses. So maybe they even know which parts are for which proteins.”

Bright Guy 3: “They’re called genes, brown-noser.”

Bright Guy 2: “Okay, genes. I don’t care what it’s called, just what it does. With that sequence can’t someone just make the protein all by himself? And why not use bacteria to make a particularly important protein for that virus?”

Bright Guy 3: “A particularly important protein?”

Bright Guy 1: “Yeah, sure. Those viruses are made out of a lot of proteins that fit together in just a certain way in order to make the structure of the virus. You know, like those old Cootie puzzles that look like bugs. A certain number of pieces of exact shapes will fit together in just the right order to make the completed Cootie, unless your little brother eats some of them or your sister goes all EasyBake on it because she hates insects. So it’s possible that if some of pieces get mutated—because you’re always hearing about viruses mutating, right—and that changes their shapes too much, then a new virus can’t assemble because those pieces don’t fit. So those are the proteins that are particularly important. Are we talking about one of those?”

Bright Guy 4: “Not necessarily. There are other viral proteins that are extremely important but that don’t have anything to do with structure and those are the proteins that viruses use to activate cell surface receptors to endocytose them into the cytosol where they can replicate. Those well-conserved proteins are super-important, sure, or they wouldn’t be so well-conserved. So in any family of closely-related viruses there are bound to be a lot of those protein pieces that are pretty much identical between members of the family no matter no matter how much other things may change.”

Bright Guy 3: “So what? If we use something that’s mutating all the time, then any protection against it by antibodies isn’t going to last very long.”

The rest all suddenly look at each other and back to Bright Guy 3.

Bright Guy 3: “What? Why are you guys looking at me like that?”

Bright Guy 2: “Bless his heart.”

Bright Guy 3: “No, seriously, what?”

Bright Guy 1: “Oh, crap, I’ll say it. ‘Out of the mouths of infants and fools.’”

Bright Guy 3: “I am not an infant.”

Bright Guy 2: “So you do know.”

Bright Guy 4: “Look, using the conserved proteins for antigens wouldn’t be cost-effective.”

Bright Guy 3: “Not cost effective? Dude, every time there’s a mutation you’d have to gear up and make another vaccine—what? Why are you guys looking at me like that again?”

Bright Guy 2: “Because if you use proteins that are highly-conserved in a virus family then that offers protection against any member of that virus family. Which means we’d be cutting the throats of a lot of different products even before they make it into the cradle because, you know, new things provide new opportunities.”

Bright Guy 4: “Back to the suggestion of using recombinant bacterial technology. Sure, it could be done, but there’s still the cost factor. So we need to come up with an quicker and easier way to make a vaccine from just a single protein that is also highly mutable and that will require frequent product updates, you know, like in-app purchases, to keep our revenue stream more or less continuous. And it also needs to be something we can promote both as a way of helping people but also as a way of keeping them safe. Those anti-vaxxers, aside from thimerosal, what is one of their biggest complaints?”

Bright Guy 1: “Oh, yeah. I got this one; my niece is an anti-vaxxer and she’s always going on and on about the child’s delicate immature immune system and the danger of overwhelming it with all the different antigens contained in those multiple shots like MMR. So, yeah, your suggestion about the single antigen could be a good selling point. And it would cut costs. What are some other ways that businesses cut costs on the sale of non-durable goods?”

Bright Guy 3: “You mean like food? That’s pretty non-durable, right? First, you’re always having to buy more of it. And people nowadays want food that doesn’t require a lot of effort but still seems homemade because that seems safer—what? You’re doing it again.”

Bright Guy 4: “Right, anything that’s bake-it-yourself, like cookie dough, okay? Or pre-made pizza crusts or focaccia. All of that heat-and-serve stuff. Not so much to do that it’s a pain in the ass but still enough effort that they can pretend it’s homemade and the company can save a shitload of money on the commercial baking and packaging end. Yes. Something like that.”

Bright Guy 3: “In other words, something homemade that will save almost all our production costs.”

Bright Guy 2: “Just how are those individual viral proteins made anyway?”

Bright Guy 1: “Yeah, here, listen. According to Wikipedia, after the virus gains entry to the cell, it basically falls apart, exposing its genetic material and I guess something in the cell makes RNA copies of all the different viral genes and then those copies—“

Bright Guy 3: “Messenger RNA because they’re carrying the message from the gene in the genome to where the protein will be made from the code they carry.”

Bright Guy 1: “Exactly, and that messenger RNA gets stuck into the ribosome in one end and the ribosome hooks together the amino acids coded for by every three bases of the messenger RNA and as the messenger RNA gets cranked through and out of one side, the protein comes out on the other.”

Bright Guy 2: “Just like an effing machine!”

Bright Guy 1: “Exactly! And the viruses are like machines. They don’t have any metabolic processes.”

Bright Guy 3: “All they need is just someone to turn the crank. Dudes, those viruses are like total freeloaders. All they do is knock on the door, the cell lets them in, the virus falls apart, that causes something else to make messenger RNA copies of all of its genes, then something else turns those into proteins using the cell’s own amino acids, then in one way or another something, not the viruses because they’ve all fallen apart, but something in the cell or something about the cell or just something about the shapes of those pieces gets them all put back together into new viruses, and then they leave to go do it again. And just how to they leave?”

Bright Guy 1, holding up his cell phone: “According to this, either they may be able to get the cell to exocytose them—“

Bright Guy 3: “Meaning?”

Bright Guy 1: “Basically, open the door and let them out.”

Bright Guy 3: “Or?”

Bright Guy 1, quickly scanning the entry: “Or basically they screw up the cell so badly jamming it with so many new viruses that it just can’t take it any more and dies and they get out that way.”

Bright Guy 3: “So they contribute nothing. They let everyone else do all the work. Meaning their cost of production is almost zero. And they end up taking everything and getting away with it. Dudes, we need to become like those viruses!”

Again, the others stare at each other, transfixed by the possibilities, and then look back at Bright Guy 3.

Bright Guy 3: “What? Why are you all staring at me again? It’s really starting to piss me off.”

Bright Guy 1: “You’re the wind beneath my wings.”

Bright Guy 3, excruciated: “Oh, man. I knew it.”

Bright Guy 4: “Relax. You’re just unexpectedly giving us all a bit of a chubby; but, you know, the good, goal-oriented, team-building kind.”

Bright Guy 3, muttering to himself: “You mean a circle jerk.”

Bright Guy 2: “No, but you’ve really got my creative juices flowing. No, listen. See, if all those viral mRNA copies get translated automatically by the cell itself into all the viral proteins using the cell’s own amino acids, then that means that just one mRNA copy could get translated automatically into just one viral protein.”

Bright Guy 1:“Or lots and lots of copies of just that one viral gene could get automatically translated into lots and lots of just that one viral protein by the cell using its own amino acids. So now we have our production facilities for free and we won’t have buy millions of eggs or invest billions of dollars paying the Chinese to force Uighurs to do it.”

Bright Guy 2: “So we’ll have cellular slave labor.”

Bright Guy 1: “And billions of free bioreactors just walking around.”

Bright Guy 3: “So where are we going to get the copy of the sequence for just that one protein?”

Bright Guy 2: “From the NIH. I know a guy. But you can just go online and download whatever you want and there are ways to synthesize that RNA once you have the code.”

Bright Guy 4: “And just how expensive is that going to be?”

Bright Guy 2: “Way cheaper than five million frigging eggs, that’s for damn sure. With one PCR machine, you can start with a few thousand copies and in a few hours end up with millions and millions of them.”

Bright Guy 3: “So basically, what you’re saying is that for not a whole lot of money we can have something that can be marketed as containing no antigen load at all. And since all the amino acids used to make it are your own, it can be described as homemade from ingredients that are already in your body and done in the safety of your own home, the ultimate in do-it-yourself home remedies—jeez, I told you guys to knock it the hell off!”

Bright Guy 1: “But you move me, man.”

Bright Guy 3, hurriedly: “Now all we need to do is to figure out a way to get it in there.”

Bright Guy 1, in too-loud aside: “Took the words right out of my mouth.”

Project manager: “I think there may be a way.”

Bright Guy 1: “An easy way?”

Project manager: “Actually a ridiculously easy way if I’m remembering correctly. There’s something we’ve been exploring for decades. It’s a way to directly target therapeutics to the site of need.”

Bright Guy 3: “Like what? How?”

Project manager: “Well, think of a tumor. It’s a bundle of cells gone wrong. Well, actually, just one cell that goes bad and then keeps continuously replicating until it gets big enough to be noticed.”

Bright Guy 3: “And then what does it do?”

Project manager: “Nothing but eat and reproduce while living off the rest of the body until it gets so big that it kills it.”

Bright Guy 3: “So, like a virus?”

Bright Guy 2: “Pretty much, and if that tumor played video games it would be like an unemployed 20-something living in his parents’ basement, just feeding, frigging, and freeloading.”

Bright Guy 4: “Back to the point. So what about these target delivery systems? Give us an idea of how they work.”

Product Manager, looking at the ceiling, searching his memory, and then brightening: “Well, imagine that twenty-something’s overburdened parents who’ve already put in their twenty and figure it’s finally time for their version of la vida loca. But they're horrified over the prospect of another twenty years wasted on the little shit, so in an effort to save what’s left after the first twenty from going down the crapper, too, they hire a contract killer to sneak into their house undetected and knock off just the obnoxious freeloader.”

Bright Guy 3: “Dude, that is way harsh!”

Project manager: “It’s a cruel world, baby. What can I say? Besides, this is brainstorming and no topic is disallowed. And, no, I don’t have a twenty-something living in the basement. I’m just using that to describe the aim of the targeted delivery systems. To find something unique about the cancer cells, maybe some specific cell surface protein expressed only on the cells of that tumor, then load up their delivery device with a drug toxic to the tumor cells, inject it into the patient’s body, and wait for it to make it to the tumor by blood flow. When it gets there, it uses those unique cell surface proteins to latch on and drop its payload of chemotherapy death into the cancer cell, and then wait for it to die.”

Bright Guy 2: “And then what does it do?”

Project manager: “It gets scavenged by the innate immune system. Oh, you mean the molecular assassin? Nothing. Its mission is done with the delivery of the drug right into the cancer cells and it probably goes down with the ship and gets cleaned up by the scavenger cells of the immune system and gets dumped with all the rest of the debris.”

Bright Guy 3: “Man, it would be a bad, bad thing if there were some other cells in the body, you know, really, really important ones, that also expressed that specific cell surface protein or something that looked just like it to the targeted delivery system. Then all sorts of perfectly good cells would be getting knocked off along with the tumor.”

Bright Guy 2: “Well, that would be a surefire way of getting rid of the tumor, right?”

Project manager: “And if my memory serves me correctly, that was one of those ‘possibilities’ that have pretty much kept it off the market and wasted huge amounts of the R&D budget. You couldn’t give Granny something that cures her breast cancer but turns around and acts like tertiary syphilis on parts of her brain and suddenly she’s a cougar with literally no libido control.”

Bright Guy 2: “Yeah, but with a healthy set of tits, right?”

Project manager: “Or you could take it for a baldness cure and it also causes your junk to fall off. But what do you care? You’ve got a full head of hair that looks fake on anyone but an 18 year old.”

Bright Guy 2: “Thanks for clarifying. I can see why you’re the Product Manager.”

Bright Guy 3: “And we can all see why you’re such a brown-noser.”

Bright Guy 4, laughing: “But back to the point.”

Project manager: “But we could use it for this because it won’t matter which cells it gets in, because it’s not going to mess with the DNA. It’s just going to do the same thing everywhere—well, probably not in the red blood cell.

Bright Guy 4: “You mean, instead of some toxic drug, we would load that drug delivery vehicle with multiple copies of a single viral RNA sequence that’s made out of the same stuff that all the RNA in the human body is made of and you could say that, basically, it mostly contained no foreign substances. Not even an antigen load. So you’re saying it would get into a cell, unload that messenger RNA, and wait for the cell to make lots and lots of protein copies of it and all of it made with the cell’s own amino acids, all natural ingredients. And then what?”

Project manager: “The drug delivery vehicle just basically falls apart after gaining access so it can release the messenger RNA to get things started.”

Bright Guy 4: “No, after the process is complete.”

Project manager: “Oh, that. Probably kill the cell by all those viral proteins getting in the way of everything else that the cell has to do to stay alive, but that gets them released to be picked up by the scavenger cells of the innate immune system and introduced to the T and B cells of the adaptive immune system that will remember it if it shows up in a virus for real and then dump antibodies on it. A few cells getting popped is a small price to pay for developing antibodies that will protect you from getting infected by any C19 viruses that make it into your respiratory system.”

Bright Guy 1, looking up from something on his cell phone: “About those antibodies. Which antibodies are they? IgG, IgA?”

Product Manager, checking Wikipedia: “Just a second. Uh, okay, both of them.”

Bright Guy 1: “And of the IgG, secretory IgG produced in the pulmonary mucosal membrane or the IgG produced by the immune system inside the body?”

Project manager: “Inside the body. What difference does it make?”

Bright Guy 1: “Because it’s the secretory IgG produced in the pulmonary mucosal membrane that can bind to C19 viruses and prevent them from using that viral protein to activate the cell surface receptors in the respiratory system to gain entry. Neither the IgG or IgA antibodies inside the body can get out there. And it’s the IgA antibodies that are the ones specific to that viral protein you’re going to use that delivery vehicle to make.”

Project manager: “Well, the overall immune response produced by the vaccine will help make the immune system generally more active, so that if any C19 make it out of the pulmonary cells and into the body, then the defense will be there.”

Bright Guy 2: “But isn’t an ounce of prevention worth a pound of cure?”

Project manager: “Only in the UK.”

Bright Guy 2: “So this really isn’t any revolutionary new thing, only a really roundabout way of doing what the traditional protein vaccines do, help to make something to shore up defenses after the structure’s been breached. So why not just do it the traditional way?”

Project manager: “It’s too expensive; it takes too long; and since it’s a proven technology it will have to go through all the protocols that already exist for those vaccines. And did I mention it takes too long? We're under the gun to get something out as quickly as possible.”

Bright Guy 2: “Then why don’t you just inject a bunch of the viral messenger RNA directly into the body? And then the adaptive immune system will make antibodies against that.”

Bright Guy 4: “It won’t have the same multiplicative effect that using it to make viral protein antigens will have and that will happen only if we get it directly into cells. And just saying, “Hey, we’re going to inject viral RNA into your body” is just way too blunt and the only thing members of the public will here is, “Hey, we’re going to inject viruses into your body” and that’s not going to fly. So it’s looking like the most effective way of getting it in there is to give it by a shot in the arm. Besides, calling it a vaccine and injecting it into the same place they’ve gotten all their vaccines will help reassure them.”

Bright Guy 3: “And what if it moves around to other places in the body.

Project manager: “It won’t. The stuff's way too big."

Bright Guy 3: "Aren't you allergic to bee stings? That bee venom doesn't just stay right around the stinger. And what about snakebites? That venom goes everywhere. And mosquito bites transfer malaria parasites and those are way bigger than particles small enough to get into cells."

Project manager: I just said we’ll administer it as an intramuscular injection so it will remain trapped right there in the deltoid muscle, you know, along with all those micro-RFID chips.”

All the Bright Guys and the manager bust a gut over that one.

Bright Guy 3: “Well, it sounds to me like you ARE injecting viruses. The product gets into the body and then sneaks into cells. It falls apart and drops a load of viral messenger RNA. It makes it possible for the cell to use the messenger RNA into bazillions of copies of viral protein at the cell’s expense. That builds up to levels large enough to kill the cells and then the proteins get picked up by cells of the immune system.”

Project manager: “Exactly, and then serve the greater good of training the adaptive immune system to prevent the scourge of Covid-19. So it’s just a matter of black box marketing. This goes in here and then that good stuff pops out there. That’s all the customer needs to know. Like sausages, right? Jimmy Dean is on this side and steaming delicious sausages are on that side. Sure, they’ll all probably feel something after the vaccination, just like nearly everybody feels something after any vaccination. But we say that's just proof it’s working and will probably make them feel better because it’s proof to them they’re doing something to keep Covid-19 from killing them. Besides, unlike viruses, it can’t replicate itself, right?”

Bright Guy 3: “Well, what if it does more than you intend for it to do? Because there are more things to life than replication.”

Bright Guy 2 snorts: “You mean like just being all you can be even if you’re a eunuch or an old maid with no issue?”

Bright Guy 3: “Well, someone may never have a quiver full of sons who can be in someone’s army but that doesn’t he’s incapable of doing other things.”

Project manager: “Like what? Not work on mutated forms of the virus? Then we’ll just make an undated version with the very mutable protein from the new version and blame having to do it on the wily character of the ever-changing virus. So like what?”

Bright Guy 3: “I don’t have to have children to be able to burn your house down or stab you through the heart.”

Product Manager, texting: “I believe that constitutes threatening or bullying behavior and I’m notifying HR about that.”

Bright Guy 1: “Belay that shit, Francis. As you already said, “this is brainstorming and no topic is disallowed.” He’s just using that imagery to compare and contrast the characteristics of viruses and the targeted delivery systems. I don’t think he’s really threatening to stab you through the heart and burn your house down on top of your twenty-something living in your basement.”

Bright Guy 3: Of course not! Why waste time on threats?”

And all four Bright guys bust a gut over that one.

Bright Guy 3: No, seriously, man, all levity aside, I mean that if the innate immune system can spot a virus infecting a cell by the presence of viral mRNA, viral protein, and unregulated protein synthesizing that messes up other systems inside the cell, then won’t this product of ours that invades a cell, dumps a load of viral mRNA into the cell, takes over protein synthesizing in an unregulated way, and produces a LOT of viral protein that messes up other systems inside the cell—well, won’t all that look exactly like a viral infection to the innate immune system? And if enough of them get into enough different kinds of cells, like the heart, the lungs—“

Bright Guy 3 looks at Bright Guy 2

Or in your case, your junk, won’t that look like there’s suddenly a giant infection everywhere and initiate the innate immune system to go on a widespread inflammatory killing spree using natural born killer cells?”

Bright Guy 1: “Can’t make an omelette without breaking a few eggs.”

Bright Guy 4: “Or a few million.”

Bright Guy 3: “But still. Couldn’t all that inflammatory immune response be enough to kill someone? Won’t that cause a huge amount of trouble ? I mean, the product will act just like a virus and nearly everything you feel from a cold or a flu is from your innate immune system fighting it.”

Project manager: “Oh, jeez, we’ll just demand from the federal government, in exchange for our coming up with such a unique and innovative system of vaccination and an unending shitload of cash from them, the guarantee that we won’t be held responsible for anything that people believe to be consequences of the vaccine. So we’ll be covered. Okay?”

Bright Guy 2: “Uh, I’m sort of with Bright Guy 3 on this one. And what do we do if folks keep alleging all this?”

Project manager: “Oh, that’s easy. We’ll just call them anti-vaxxer, conspiracy theorists and January 6 Trump insurrectionists who are always fighting scientific progress and thinking that progressive socialists are under every rock; we’ll do what was done with those who wouldn’t buy the whole global worming thing only worse.”

Bright Guy 3: “Worse? Why?”

Project manager: “Because when they’re dissing what you say about climate 200 years in the future, ridicule is enough. But when their talk endangers health and safety and threatens life right here in the present, then no action is too extreme to stop them.”

Bright Guy 3: “The health and safety of what ? And whose life is being threatened?”

Project manager: “The life of our company and the health and safety of our product line, our jobs, and 401K plans.”

***

Wild Type Virus Versus Viral mRNA Product Side by Side Comparison

So here’s a side by side comparison of the most important features of what a virus does and what their products do:

A. Where it goes:
1. A virus gets into living cells,
2. Their products get into living cells

B. What it does:
1. A virus unpacks its genetic material and makes a LOT of viral mRNA copies of all the viral genes
2. Their products unpack the genetic material they contain, either many viral mRNA copies of one viral gene or many little circular RNA vectors containing the viral RNA for one viral gene from which is made many viral mRNA copies of that one viral gene.

C. What happens next:
1. The virus’s viral mRNA interrupts the cell’s normal protein production
2. Their products’ viral mRNA interrupts the cell’s normal protein production,

D. For what purpose?
1. The viral mRNA uses the machinery and the cell’s amino acids and energy resources to make a LOT of new protein copies of all the different viral genes.
2. Their products’ viral mRNA uses the machinery and the cell’s amino acids and energy resources to make a LOT of new protein copies of just the one viral gene for a viral spike protein.

E. What happens next:
1. All the many new protein copies of the viral mRNA copies of the viral genes use the cell to reassemble themselves into many brand new viruses.
2. All the many new protein copies of the products’ mRNA copies of just one viral gene just keep building up as long as there are copies of viral mRNA to translate and enough amino acids to use.

F. The next step in the cycle:
1. The growing number of new viruses exit the cell either by exocytosis or by killing it from their sheer volume and then go drifting off to do it again.
2. Their products’ growing numbers of copies of just that single protein exit the cell by killing it from their sheer number and then go drifting off.

G. Until THIS innate immune system event happens:
1. The virus’s viral mRNA and viral protein are detected in the compromised cell by the innate immune system (2).
2. Their products’ viral mRNA and viral protein are detected in the compromised cell by the innate immune system.

H. And then:
1. The cells packed with viruses and viral mRNA and viral protein are attacked and destroyed by the different components of the innate immune system
2. The cells packed with their products’ viral mRNA and many, MANY copies of just that one viral protein are attacked and destroyed by the different components of the innate immune system.

I. So what does it all mean?
It means that those products function as artificial viruses to sneak viral RNA into cells to produce viral protein (though the AstraZeneca version uses an actual replication-disabled chimp adenovirus to do it) and, while they can’t make new versions of themselves from many copies of the one single viral protein, the results are still treated by the innate immune system at least in the same as an actual viral invasion.

J. Only worse because
1. Respiratory viruses are tissue-specific for the respiratory system.
2. Their products are NOT tissue-specific, do not stay at the site of injection on the arm, but have been found to be disseminated through up to 3/4 of the rest of the body.

K. How much worse?
1. Respiratory viruses and the cells they are in are attacked by tissue-specific elements of the innate immune system in the respiratory system.
2. The many different types of cells their products indiscriminately have invaded with viral mRNA and have gotten packed with viral protein are attacked simultaneously by elements of the innate immune system specific to all those different systems.

L. How the innate immune system responds:
1. Upon detecting respiratory viruses in cells: “Oh, part of the respiratory system is under attack! Mobilize the appropriate level of immune response in that region.”
2. Upon detecting in cells of numerous systems the presence of their products’ viral mRNA, viral protein, and disruption of normal cell processes: “Oh, shit, we are under simultaneous attack in many different systems by some unknown viral agent that is already inside the cells and replicating. Throw all available resources at it everywhere and kill it before it can kill our host.”

J. The outcome:
1. Respiratory viruses: outcomes range in severity based on the type of virus, the initial load of the virus, and the health and immune state of the victim; immunological outcome: sequestration by innate immune cells of viral protein debris and, in the case of Covid-19 Mark I, robust, long lasting adaptive immune response to a diverse range of viral protein antigens and adaptive immune system resistance to any other viruses sharing highly conserved genes, the degree of resistance proportional both to the number of conserved genes and to the degree to which their divergence does not disrupt shared identical epitopes for antibody recognition and binding on the proteins those genes code for.

2. mRNA vaccine products:

a. ranges in severity based on the number of systems affected, the number of cells in each system compromised by the products’ mechanism of action, the initially limited sequestration of naked viral spike proteins and all the consequences entailed by that (probably thrombosis), and the level of damage caused by inflammatory response, which, upon examination, in the absence of clear indications of pathogen involvement, if spotted at all, will be taken to be an auto-immune attack or “antibody enhanced immune response.”
b. immunological outcome: limited, short-duration adaptive immune response to a single viral protein antigen and little to no adaptive immune response to any variant with mutations of that spike protein, depending on the extent of mutations and the degree of alteration of all possible prior epitopes on that single antigen.

K. Real world outcome:
1. Viruses: disease states that have been fairly well characterized for known pathogens.
2. mRNA vaccines: disease states much less easy to characterize because:
a. They haven’t been around very long,
b. They can affect multiple systems to varying degrees, depending on the characteristics of the delivery vehicle, extent of exposure, frequency of exposure, gender, developmental age, number and extent of preexisting disease states, prescription and OTC drug interactions, immune state, and unique genetic background both individual and racial, etc.
c. There may be no identifiable pathogen-based active disease state or other information to draw attention to the actual source of the cause of death.

For example:

A group of 15 patients autopsied at the request of family following official pronouncement of cause of death and no official mention made of vaccination status, showed, on more detailed examination at the tissue and cellular level, unmistakable signs of inflammatory attack, all 15 on the heart, 14 on the lungs, and a few showed signs of inflammatory attack on other organs in addition to the heart and lungs.

The type and extent of the damage was enough to kill them but the signs were not visible in gross inspection of organs in any initial autopsies performed (3).

Normally this kind of damage would be labeled auto-immune damage because of no signs of infection by pathogens.

But all the deceased had been vaccinated with mRNA products, the principal mechanism of which mimics viral infection and which recruits the same attack response of the innate immune system as infection by viruses.

Bottom line:

A. Traditional protein vaccines are used to introduce proteins of pathogens to the site of injection and, with the possible exception of vaccines using weakened but active viruses, they do NOT invade and compromise healthy cells and are sequestered by cells of the innate immune system.

Those proteins are cleaned up as routinely as any others by cells of the innate immune system and presented to the T and B cells of the adaptive immune system to develop antigen-specific antibodies against a future encounter.

B. The mRNA vaccines. Every cell invaded by the product is a cell that becomes dysregulated by the intended mechanism of action of the product and subject to damage or death by the intended mechanism of action of the product or to being destroyed by the innate immune system because the intended mechanism of action of all these products make them appear to the innate immune system to be indistinguishable from virally-infected cells.

The only thing worse that could be done using such delivery vehicles and this principal mechanism of action would be to use it to introduce the mRNA for a prion or maybe antisense RNA to disable the mRNA used for proteins destined for upkeep or proliferation of mitochondria, including crucial proteins in the electron transport chain or to produce large quantities of proteins able to increase or inhibit neurotransmitter production or to block neurotransmitter function.

All of these and many other functions can be impaired by pathogens or chemical agents with deadly results. But they could also be disrupted by selectively manipulating cellular processes involving protein synthesis by blocking it or using it to produce exogenously-designed custom proteins that can, by sheer quantity, target them.

Upon toxicology screens at autopsy, nothing will be detected as an exogenous chemical agent because it was an exogenous informational agent encoded in RNA or DNA, expressed through malicious proteins or maliciously increased or decreased levels of completely normal proteins.

A WHOLE lot of things could easily go very wrong very quickly without ever having to worry about traditional chemical or biological warfare involving the indiscriminate use of infectious pathogens or chemical agents, not as long as you’ve established a worldwide distribution chain for a product you’re making people believe is crucially important for keeping them alive.

With that, all you have to do is to choose what you want to package for what outcome, select the desired zip code and then?

Almost instant agony or annihilation produced courtesy of your victims’ own body in the comfort of their homes.

____________

1. https://microbiologyinfo.com/techniques-of-virus-cultivation/

2. Bhakdi, S. and Burkhardt, A. (2021) On COVID vaccines: why they cannot work, and irrefutable evidence of their causative role in deaths after vaccination

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507498/

[aruanan]

I wrote some of this for a woman who said she didn’t understand what I was saying about the immunology and the viral mRNA vaccines but that she, herself, had suffered adverse events from one of them.

[JennysCool]

Still in the midst of reading, but had to give you kudos for excellent writing. Very readable and lots of wit. Thanks for posting!

[bitt]

love it!

[Widget Jr]

That’s a lot, it will take time to digest it all. You went to grad school 25 years ago? Was it medical?

[Jet Jaguar]

Bump

[Fractal Trader]

Good stuff!

[BenLurkin]

Gads, this is well-written.

Astonishingly well-written.

[Jamestown1630]

After taking up so much bandwidth, would you like to post your real name and C.V.?

[ifinnegan]

There’s another term for mRNA vaccine: placebo.

[El Cid]

self-ping

[Robert DeLong]

Finish later, where I am more awake and able to comprehend better. But what I did read was impressive. Look forward to reading it with more attention then I am currently able to afford.. 🙂

[grey_whiskers]

You win Free Republic.

Deeply impressed, thanks for writing this.

[grey_whiskers]

Thanks to aruanan for an epic.

PING to some others.

[Jane Long]

Ping to a great read.

[Karliner]

wow

[Navy Patriot]

How's this for a analogy:

You notice a mosquito lands on your stomach.

You use a flyswatter to swat the mosquito, or

you select the mRNA method, you swat every single cell in your body with the same force generated by the flyswatter.

(In other words, the swatting force multiplied by one hundred trillion, 100,000,000,000,000)

That's gonna hurt.

[Navy Patriot]

Sorry, How’s this for AN analogy?

[El Cid]

Thanks - a long essay (I’m used to single sentences populated with mono-syllables), but very educational and easy to read. Thanks for your effort, and for posting it.

[ransomnote]

PING