Click image for article with references to a number of studies.
It's all about balance.
Posted on 06/08/2022 9:49:02 PM PDT by ConservativeMind
A team of researchers has found that a metabolite produced by bacteria in the gut promotes neural cell death resulting in cognitive decline in mice. In their paper, the group describes their study of the metabolite isoamylamine (IAA) and its impact on cognitive decline.
Prior research has suggested a strong link between gut bacteria and brain health. The researchers looked into the possible impact on the brain of just one metabolite produced by one family of bacteria in the gut, Ruminococcaceae.
They found first that IAA becomes more prevalent in the gut as people age due to the presence of more Ruminococcaceae. Their interest in IAA grew when they learned it could pass through the blood-brain barrier. In order to trace the path of IAA from the gut into the brain to see what impact it might have, they had to develop a new technique—a modification of electrophoresis that allowed for the tracking of DNA mobility shifts—which they called single-strand gel shift. They next incubated the gene responsible for sensing and responding to aging in mice (S100A8) with IAA. They found the metabolite binds to a promoter region of S100A8, which allowed for expression of the gene, resulting in production of apoptotic bodies, which lead to cell death.
To learn more about what happens when such bindings occur, the researchers fed IAA to young healthy mice and determined that this resulted in a loss of cognitive function. They next blocked production of the metabolite in the guts of older mice and found that it led to improvements in cognitive performance.
They state more research needs to be done to find out if the production of IAA in the human gut biome also results in cognitive decline, and if so, whether blocking its production would prevent cognitive decline as people age.
(Excerpt) Read more at medicalxpress.com ...
Waiting for the other shoe to drop: the roster of all the great foods that we’ll need to avoid to stave off bathing our brains with this gut-produced toxin.
AND, too, I expect there’ll be some reason this specific bacterial strain CANNOT be entirely eliminated from the gut; probably THAT’D kill ya, too, if Murphy’s Law is of any effect.
Click image for article with references to a number of studies.
It's all about balance.
Unfortunately probiotic organisms don’t have any effect on actual gut bacteria. There are upwards of 28 strains of lactobacillus and acidophilus which are what yogurt and kefir are made by. Then there are the leuconostoc bacteria that are responsible for sauerkraut and kimchi. You can easily consume a trillion live cultures of probiotics in a day and it will have no noticeable effect on your health. I think going to Mexico and drinking a glass of water would be more effective.
I thought that was a quaint fishing village in Wales.
“Ruminococcaceae...”
[slaps forehead] But of course!! How did I overlook it?
Btt
Too many vowels.
FWIW, I just looked at a bunch of papers published in the last few months that argue otherwise.
I’ll keep drinking the kefir. :-)
Don’t believe a word of this.
It conflicts with prior ‘studies’ and illustrates how they STILL know next to nothing about the gut.
It’s both a ‘little’ more complicated and much simpler than what profit-driven research suggests.
I was trying to dig into other research on this, and I am thinking this issue becomes prominent with older people, due to the loss of other processes to mitigate it.
Address those other processes, and you could be back to normal.
Younger people eating a lot of fiber aren’t getting dementia, I wouldn’t think. Heck, I’ve been trying to encourage the short chain fatty acids some of these same bacteria form.
Still, it does seem a legitimate problem for older people, and I’m fast becoming one.
It has much more to do with circulation, but toxins resulting from gut dysbiosis exacerbate the problem created by systemic inflammation.
They already proved that Alzheimer’s is a consequence of circulatory disorder. The problem is that they couldn’t find a way to profit from a corrective measure so the research was ignored and somewhat buried…just like all the other inconvenient research.
Best advice for the you/the aged:
Get in the pool and exercise 3-4 times a week at a minimum and don’t eat out with rare exception & narrow qualifications for said meals.
“Too many vowels.”
Must have been named by a mica-ca-crobiologist with a stuttering problem.
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