Yep. If you're taking a cheap multivitamin from Target or Walmart, you might want to reconsider.
For example, if you happen to be one of millions of Americans who have a grouping of genetic mutations (and almost everyone has at least one of these mutations), you cannot process B vitamins without folate. Cheap brand multivitamins add synthetic folic acid instead of bioavailable methylated folate. But here's the thing... if you have several of these mutations, folic acid is actually toxic to your body and it builds up in your system, causing a multitude of issues that are factors in an assortment of other diseases (i.e., depression, hypothyroidism, extreme anxiety, high levels of homocysteine leading to cardiac issues, etc.). Not to mention, you can take $$$ worth of B vitamins and your body will just pee them straight out.
More info... https://www.healthline.com/health/mthfr-gene#treatment
I also should mention that folic acid is added to almost all
processed foods claiming “enriched flour.” Pastas, bread, crackers, cereals, etc. If you have a sensitivity to wheat products, you might find that you also have multiple MTHFR gene mutations and are actually reacting to the folic acid.