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Iron deficiency suppresses important arm of the innate immune system
Medical Xpress / German Cancer Research Center / Science Advances ^ | Oct. 7, 2022 | Michael Bonadonna et al / Joe N. Frost et al

Posted on 10/08/2022 9:24:29 PM PDT by ConservativeMind

Two proteins ensure that cells can take up iron when needed. If both control proteins are switched off in mice, the animals develop severe anemia, as expected. At the same time, surprisingly, a cell type of the innate immune defense, the neutrophils, also dramatically decreases. Iron deficiency, a known defense mechanism against infectious pathogens, is a double edged sword, as it simultaneously curbs the defensive power of an important arm of the innate immune system.

"This strong iron dependence of neutrophils was previously unknown. It possibly affects the immune defense against bacterial pathogens," says Bruno Galy. Interestingly, on the other hand, iron deficiency is one of the body's defense strategies in bacterial infections: many pathogens are dependent on iron. To slow down their multiplication, the body hoards the metal in certain cells that serve as a storage chamber to make it more difficult for pathogens to access this valuable resource.

Another publication demonstrates that iron deficiency in blood serum, as typically occurs with infections, leads to a decrease in neutrophils in mice and limits the ability of these immune cells to fight bacteria. "Iron deficiency apparently modulates the innate immune system. It suppresses the maturation of neutrophils and also throttles their defensive power," says Bruno Galy. "The limitation of available iron is apparently a double-edged sword: On the one hand, the body thereby prevents bacteria from spreading. On the other hand, the function of an important arm of the innate immune system suffers."

Not only infections but also inflammations often lead to iron deficiency and thus to anemia. Cancer patients whose disease is accompanied by chronic inflammatory conditions are therefore often affected by anemia, which can severely limit their quality of life.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: anemia; bacterial; cancer; immunesystem; iron; pathogens
You want enough iron, because your body will choose to reduce its availability, when needed, to deal with pathogens.
1 posted on 10/08/2022 9:24:29 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 10/08/2022 9:25:06 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

” Beef! it’s what’s for dinner “


3 posted on 10/08/2022 10:48:05 PM PDT by nevermorelenore ( If My people will pray ....)
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To: ConservativeMind
You get iron from food containing two types of iron, heme and non-heme. Your body readily absorbs heme iron from meat, poultry, and fish. Non-heme iron is plant-based.
4 posted on 10/09/2022 2:40:36 AM PDT by Boomer (I love my country but am ashamed of my current government.)
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To: ConservativeMind

Steak cooked on a cast iron skillet gives me the iron I need.


5 posted on 10/09/2022 4:15:55 AM PDT by Bayard
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To: ConservativeMind; ransomnote; Jane Long; nickcarraway
Speaking of anemia, a different type, a paper from May...

Acquired aplastic anemia following SARS-CoV-2 vaccination

6 posted on 10/09/2022 4:21:06 AM PDT by mewzilla (We need to repeal RCV wherever it's in use and go back to dumb voting machines.)
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To: mewzilla
One more...

Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine

Love this part...

...As efforts to administer SARS-CoV-2 vaccines continue globally, clinicians must be aware of potential autoimmune sequelae of these therapies...

YA THINK?!?

7 posted on 10/09/2022 4:23:37 AM PDT by mewzilla (We need to repeal RCV wherever it's in use and go back to dumb voting machines.)
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To: mewzilla

We’re just more of Fauci’s beagles to these people.


8 posted on 10/09/2022 4:25:34 AM PDT by mewzilla (We need to repeal RCV wherever it's in use and go back to dumb voting machines.)
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To: ConservativeMind

Eat your liver and onions!


9 posted on 10/09/2022 5:52:34 AM PDT by glorgau
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To: ConservativeMind

bump


10 posted on 10/09/2022 8:46:48 PM PDT by Albion Wilde (Stand fast therefore in the liberty by which Christ has made us free... Galatians 5:1 )
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To: ConservativeMind

Reminds me to get a once a month Filet.

:^)


11 posted on 10/09/2022 8:53:36 PM PDT by eyedigress (Trump is my President!)
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