Posted on 12/07/2022 5:04:05 AM PST by tired&retired
Now, using a mouse model of Alzheimer's disease, a team from Yale University in the US may have figured out why the patches of protein seem relevant without necessarily being directly responsible.
"We found that hundreds of axons develop [swelling] around each amyloid deposit," Yale University neurobiologist Peng Yuan and colleagues write in their paper.
They found the swelling is formed by a buildup of lysosomes – little bin-bag-like compartments created by cells to break down waste and contain it until it can be removed. These lysosomes clump into spheroid structures along the axons of brain cells – the long 'transmission cable' that extends from the cell's body, and ends in branches of signal-sending extensions.
(Excerpt) Read more at sciencealert.com ...
The team found that high levels of PLD3 occasionally led to lysosome enlargement even in healthy mice. However, it was more pronounced in the spheroids located near the amyloid plaques in the mice with Alzheimer’s, suggesting something about the plaques exacerbates the swelling process.
https://youtu.be/WLxbTI
Q8cqo
So something is keeping the brain from taking out its trash...?
So, basically, Alzheimer’s is the result of the brain’s ability to communicate being shut off by too much garbage building up?.................
Did the janitors go on strike?
More ignorant research which underpins that which already proved the cause of Alzheimer’s, without citing those discoveries whatsoever.
Laughably pathetic. Maddening.
There is FAR too much money financing research lacking results and the promising research has been quashed in favor of continuing worthless research.
Enjoy. /s
Yep. Others already proved it (recall ‘microbubbles’).
But the discovery was too revealing: All consequent research ignores it in total in favor of continued ‘research’ ($$).
Alzheimer’s/dementia are my biggest fears about growing old. Losing myself and everyone I love frightens me.
Types of fasting include dry fast for a day, fasting mimicking diet for 5 days, intermittent fasting (various types such as alternate day, 6/18, 7/17, 8/16), water only for a few days, etc.
The keto diet may help, but FMD definitely will (<16g protein, <50g carb, <800cal). Alternate low-protein days may help.
Foods that induce autophagy include green tea, berries (especially blueberries, raspberry), cacoa, cinnamon (especially Ceylon), pomegranate (fruit), red grapes (black?), coffee (turmeric/curcumin), ginger, cruciferous vegetables, coconut oil. Of course avoiding anti-autophagy foods helps too.
Fasting ought to promoted as a normal lifestyle. Muslims and Adventists do. It is a Biblical practice, but I suppose few Christians realize the many physical health benefits.
Look on the bright side, you will also forget the last two elections ever happened ...
The Catholic Church used to have rules for fasting in Lent and Advent but those have been reduced to almost nothing (fasting on Ash Wednesday and Good Friday—but young people and people over 59 are not required to comply). Probably the majority of Catholics are not even aware of those rules. I think the Orthodox Church still has fasting during Lent.
Cacao? So chocolate is a health food after all.
Cacao has not been roasted at high heat and it best. Cacao nibs are pieces of the bean. Our Costco has cacao powder. Dark chocolate is good too. I like the 85% Moser bars from Aldi.
“Dark chocolate is good too.”
Yeah, I don’t think milk chocolate does anybody much good, unless they are low on blood sugar.
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