Posted on 01/25/2023 2:02:10 PM PST by ConservativeMind
Josep Tabernero presented data at this week's American Society of Clinical Oncology's (ASCO) 20th Annual Gastrointestinal Cancers Symposium.
This open-label controlled two-arm, phase III comparison study was designed to validate the efficacy and safety of the orally administered combination of trifluridine/tipiracil plus monoclonal antibody bevacizumab versus trifluridine/tipiracil alone in the third-line treatment of patients with refractory metastatic colorectal cancer (mCRC) who had progressed after two lines of prior therapy.
Around 50% of colorectal cancer patients will ultimately develop metastasis, with a five- year survival rate of only 11%. The prognosis for patients with refractory disease remains poor, with median survival generally between 4-8 months. With limited treatment options available, the standard of care for this patient population currently includes trifluridine/tipiracil or regorafenib as monotherapy, or in combination with other approved agents for some patients.
The SUNLIGHT study investigators reported an improved median survival of 3.3 months with trifluridine/tipiracil plus bevacizumab, from 7.5 months with trifluridine/tipiracil monotherapy to 10.8 months with the combination regimen.
Progression-free survival was 2.4 months with trifluridine/tipiracil alone versus 5.6 months combined with bevacizumab. Time to deterioration in global health status was 4.7 months and 8.5 months, respectively. Quality of life was graded according to the ECOG Performance Status Scale. Median time to worsening to a grade 2 or more was 9.3 months with the combination compared with 6.3 months in those patients receiving trifluridine/tipiracil alone.
"In addition to the magnitude of benefit observed in patients who received the combination, adding bevacizumab to trifluridine/tipiracil did not increase the risk of serious adverse or adverse events. Improved survival was observed across all subgroups independently of tumor sidedness, RAS mutational status, and receipt of prior bevacizumab, indicating that the combination regimen is an option for all clinically relevant subgroups," adds Elena Élez.
(Excerpt) Read more at medicalxpress.com ...
These monoclonal antibodies are life savers.
Truly.
No trials or studies, just lab testing.
Search: nih.gov Ivermectin colorectal cancer.
Ivermectin seems to be coming on strong as a cancer drug.
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