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Study provides new insights for prevention and treatment of colon cancer by probiotics intervention
Medical Xpress / Chinese Academy of Sciences / Microbiology Spectrum ^ | Sept. 14, 2023 | Liu Jia / Fuqiang Xu et al

Posted on 09/17/2023 11:22:05 AM PDT by ConservativeMind

Researchers suggest that the intervention of probiotics is a potentially feasible strategy for preventing colon cancer.

Colorectal cancer is the third most common cancer worldwide. Most patients are diagnosed at the middle and advanced stages due to the longer development of malignancies in the colon and rectum, as well as higher concealment compared to other cancers, which results in a narrow treatment window and high mortality rate.

Gut microbiota and their secreted metabolites have a significant influence on the initiation and progression of colon cancer.

The researchers at IMP have irradiated probiotic JY strain by heavy-ion beams, and obtained an excellent mutant strain JY300-8 through selections of transit tolerance in the upper human gastrointestinal tract. In addition, from the intestine of mice with complete tumor remission, they isolated a strain of L. reuteri with a strong anti-proliferation ability on tumor cell.

After investigating Lactobacillus for colon cancer, the researchers found that the inhibition rates of these probiotics against mice colon cancer cells and human colon cancer cells were more than 50% and 70% respectively, reaching a higher level in similar research. They also found that dual probiotics could reduce the tumor formation rate and tumor volume, and could significantly inhibit the progression of tumors in colon cancer susceptible models in mice.

In addition, the researchers revealed the underlying antitumor mechanism through the alteration of gut microbiota and their metabolites. They combined the carbon ion radiation therapy with gut microbial therapy for the first time, which increases the survival rate of colon cancer model in mice by 50% compared with the control group.

This study enriched the resource of probiotics, and provided a tumor treatment strategy by combining the carbon ion radiotherapy with the gut microbial therapy, laying a theoretical foundation for the precise prevention and management of colon cancer.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; coloncancer; gitract; gutbacteria; medicalxpress; probiotics
Irradiated probiotic bacteria strains L. casei JY300-8 and L. reuteri JMR-01 inhibited cancer 50% and 70%, respectively, and together, could reduce colon cancer tumor volume.

Normal strains should still help, but not likely anywhere to this extent. You can buy these probiotic bacteria, in many such supplements and some yogurts and kefirs.

1 posted on 09/17/2023 11:22:05 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 09/17/2023 11:22:38 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: All

I consume Greek yogurt, kefir milk and sauerkraut. Just a preventive measure. And I have been inundated with cologard fecal sample requests this year. I gave one in March and every 2 months since then I’m sent reminders and once a kit from my insurance. Just how many do they want from one person in a year? It’s starting to look like a fetish.


3 posted on 09/17/2023 11:40:25 AM PDT by BipolarBob (Biden would give Jesse James the train schedule for his 10%.)
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To: BipolarBob
I like yogurt, but just don't like Greek yogurt (even the vanilla flavored). Wonder what is a good probiotic to take. I use to take Natures Valley probiotic capsules, but stopped. Didn't know if was helpful or not.

My wife and I eat LOTS of fresh green salads, almost every night for dinner. Wonder if that helps...

4 posted on 09/17/2023 11:44:15 AM PDT by jeffc (Resident of the free State of Florida)
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To: BipolarBob

Oh yeah (forgot). The fecal sample kits. My Dr. is keen on those. Mine always come back negative.


5 posted on 09/17/2023 11:45:56 AM PDT by jeffc (Resident of the free State of Florida)
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To: jeffc

You don’t like the flavor or texture or what about it? Can you add anything to it to enhance it or do you have some side effects from it?


6 posted on 09/17/2023 11:47:12 AM PDT by BipolarBob (Biden would give Jesse James the train schedule for his 10%.)
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To: BipolarBob

It just tastes too sour-like to me. My wife loves it, though. Guess I’m just too used to the old regular stuff, LOL. Tough to teach an old dog new tricks.


7 posted on 09/17/2023 11:53:07 AM PDT by jeffc (Resident of the free State of Florida)
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To: jeffc

Texture is good. Don’t like that thin Yoplait stuff. Add my own fruit to plain yogurt, I’m good to go!


8 posted on 09/17/2023 11:54:22 AM PDT by jeffc (Resident of the free State of Florida)
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To: jeffc

The best thing to do is eat a wide variety of fermented foods (they each have their own bacterial colonies) as well as resistant starch and soluble and insoluble fiber. If you don’t give the good gut guys food, they die off and don’t produce the butyrate and acetates and other SCFAs.

IANAD


9 posted on 09/17/2023 11:55:41 AM PDT by CrazyCatChick (DEATH POKE!)
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To: CrazyCatChick
I like fermented grapes that have been stored for a while.

=:-)

10 posted on 09/17/2023 12:04:27 PM PDT by jeffc (Resident of the free State of Florida)
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To: jeffc

I love Greek Yogurt, especially vanilla 0 fat from Trader Joe. I mix frozen blueberries into it and have it for dessert most nights. Trader has organic wild blueberries, the best. Very good for you. You can buy frozen blueberries everywhere. Safeway has great organic blueberries in the freezer. Also strawberries.


11 posted on 09/17/2023 1:29:57 PM PDT by Veto! (FJB Sucks Rocks)
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To: ConservativeMind

Now, all I need is the iPhone 15 in my pocket for a little radiation, and I’m good to go!


12 posted on 09/17/2023 2:02:18 PM PDT by SgtHooper (If you remember the 60's, YOU WEREN'T THERE!)
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To: Veto!

I would love to be able to eat any of those berries but the seeds are great for generating Diverticulitis. I don’t like Yogurt. I suppose I can try harder to eat the Yogurt. I seem to be doing ok with what I’m eating. I’ve made it to 90 and taking care of myself.


13 posted on 09/17/2023 2:56:56 PM PDT by WVNan
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To: WVNan

No seeds in blueberries. I buy them frozen.


14 posted on 09/17/2023 9:31:09 PM PDT by Veto! (FJB Sucks Rocks)
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To: SgtHooper
Yeah, I was wondering where I can get some irradiated probiotic bacteria.

But what about those probiotic supplement pills/drinks? Do they do any good or are you just wasting money buying them?

15 posted on 09/18/2023 3:45:44 AM PDT by jeffc (Resident of the free State of Florida)
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To: ConservativeMind

There was an article on Daily Mail, today, along with pictures of recent young victims of colon cancer that made me wonder if this recent outbreak of colon cancer among young adults could be related changing sexual practices and herpes.

Herpes causes ovarian cancer and esophageal cancer. So, maybe it also causes colon cancer.


16 posted on 10/15/2023 5:21:32 PM PDT by Eva
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