Yep, the golden rule.
I've tried many supplements which included NAC (my system wouldn't tolerate it), Nattokinese (does absolutely nothing), Selenium (again, my system couldn't tolerate it), and a few others. The only things I take these days are doctored recommended Vitamin D and Niacin. That's it.
You may have genetic drug toxicity issues. If you have your DNA you can upload it to genetic genie to help pinpoint it but 23andme DNA test really isn’t good enough.
I have a genetic variation that has been shown to have good response from naltrexone and sure enough it works great on me but I don’t use the wellbutrin combo.