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I have had soursop in a dessert form it tasted great. Mexican stores would have it as “guanábana.”

In reviewing what is available on soursop, the seeds appear to encourage Parkinson’s Disease-like issues, but don’t eat them. Unfortunately, there is always a possibility you get a seed, ground or whole. I would imagine whole could be less a problem, and maybe make it through without breaking down.

The sweet fruit is tasty, but doesn’t seem to have the benefits the soursop leaves appear to have, which may help with blood pressure and cancer, according to what I’ve seen. That said, these benefits, where they stem from alkaloids, instead of antioxidants, are more problematic. Additionally, without knowing the other components in leaves and not getting standardized extracts, you don’t really know what you are getting.

I am very cautious with any alkaloidal benefit, as alkaloids can interfere with needed processes and even benefits from other foods or medicines. One should always be very careful with them.

Depending on what was the concern, I’d go to other nutraceuticals that had more studies, rather than rely on soursop. For instance, there is a lot more on grape seed extract working against cancer, than soursop. There are also reliable brands from which to get the extract. From the brands I see on Amazon, I’d consider Piping Rock over the others, just because Piping Rock had a Top Pick on ConsumerLab for a completely different supplement. That said, it appears there is no substance any of the supplements on Amazon attempt to provide in an extract, save for getting rid of water and fiber, simply making the extracts “condensed” forms of the leaves. If anyone actually knew a component that was helpful, they would describe the amount of that component left in the extract—but no company seems to know, or care, apparently. So all the extracts I saw seem no different than simply eating a bunch more leaves, while you don’t even know what else is in those leaves.

I would not utilize soursop leaves, or their condensed form in an “extract,” at this time. However, the fruit, minus the seeds, and any concentrate of that, could be worth trying and enjoying.