Posted on 12/17/2023 8:24:14 PM PST by ConservativeMind
Research has revealed how, in diabetics, high levels of blood sugar disrupt the function of key cell subsets in the lungs that regulate the immune response. It also identifies a potential strategy for reversing this susceptibility and saving lives.
Prof. Eran Elinav's team subjected multiple mouse models of types 1 and 2 diabetes to a variety of viral lung infections. The immune reaction, which in nondiabetics eliminates the infection and drives tissue healing, was severely impaired in the diabetic mice, leading to uncontrolled infection, lung damage and eventual death.
"High blood sugar levels severely disrupt certain subsets of dendritic cells in the lung, preventing these gatekeepers from sending the molecular messages that activate the critically important immune response," says Nobs. "As a result, the infection rages on, uncontrolled."
Importantly, the scientists discovered how high sugar levels in diabetic mice disrupt the normal function of lung dendritic cells during infection. Altered sugar metabolism in these cells led to the accumulation of metabolic byproducts that markedly disrupted the normal regulation of gene expression, leading to aberrant immune protein production.
"This could explain why the functioning of these cells is disturbed in diabetes, and why the immune system is unable to generate an effective anti-infection defense," says Kolodziejczyk.
The scientists next explored ways to prevent the harmful effects of high sugar levels in lung dendritic cells, as a means of lowering the infection's risk in diabetic animals. Indeed, tight control of blood sugar levels by insulin supplementation prompted the dendritic cells to regain their capacity to generate a protective immune response that could prevent the cascade of events leading to a severe, life-threatening viral lung infection.
"Correcting blood sugar levels enabled our team to get the dendritic cells' function back to normal," says Abdeen.
(Excerpt) Read more at medicalxpress.com ...
Diabetics, do not let your blood sugar wander up, when having a serious infection
Put that spoon down,and step away from the Häagen-Dazs® Ice Cream!
Yes, and potatoes, rice, pasta, Bread, and most fruit.
Perhaps the low sugar level in chicken soup is one reason why it is traditional to eat when you have a cold?
Bkmk
Bump for reference
Not always. Sometimes the way you cook and serve foods makes a huge difference on a person's blood sugar readings.
One interesting fact is that if you say fully bake a small Russet potato, and then refrigerate it for a day, then briefly reheat it for the next night's dinner, you have dramatically lowered it Glycemic Index. The cooking, then cooling then slight heating changes the starch molecules and how the body processes them.
Cooking really is chemistry in action, if you look at it the right way. Enjoy the following scientific study Abstract in the URL link. Lots of fruits and some breads are not as bad as they are normally thought of, again, how the ingredients are processed and then made into the final product makes a huge difference.
“....eating cooled or reheated potatoes reduces their GI by 30–40%. The aim of this study was to see if cooling and reheating had the same effect on the GI in different potato varieties. Thus, we determined the GI of four different types of potato, each of which was boiled and served in 3 ways: freshly cooked, cooled and served cold, or cooled and reheated. ANOVA showed, no main effect of potato variety, but a significant main effect of cooling with cold potatoes having a lower GI than freshly cooked or reheated potatoes (P<0.05). However, there was also a significant cooking*variety interaction, with cooling having a significantly greater effect in one variety than two of the others (P<0.05). We conclude that the effect of cooling and reheating on the GI of boiled potatoes differs in different varieties.....”
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.24.1_supplement.553.2
you have dramatically lowered it Glycemic Index.
I’m in when it works for pizza...
bkmrk
It called “Resistant Starch” when Potatoes and Rice are cooked then cooled. You are correct, it changes the way your body digest them.
If my wake-up blood sugar is below 100 does the rest of the day matter?
If you are diabetic that’s a good number to wake up to.
If you’re on insulin, try to keep your BS to under 200 at the highest, like right after a meal. It’s always a race between a meal and a bolus shot. Don’t fret the highs if your bolus can bring them down soon enough.
I’m pre. Is that still too high?
I’ve gone Keto. 2 meals a day in a 6 hour window. Minimal carbs. Fruits consist of mainly berries. Mixed nuts (walnut, almond, ...). Meals usually with turmeric, black pepper, olive oil.
Lost weight. Never seem to have cravings.
Fasting overnight 12 hours should fall between 70-100, a 125 is concerning after a 12 hour fast, During the day as you eat it should stay no higher than 125. Over 125 on 2 tests fasting is considered pre diabetic, over 200 on 2 tests fasting is diabetic.
D3........ .>10,000/day
No respiratory problems.
I am diabetic type II for 16 years
I apologize I mixed up my numbers, over 126 on 2 tests fasting is diabetic, not 200. I’ll let Mayo Clinic explain it better.
Diagnosis
Type 2 diabetes is usually diagnosed using the glycated hemoglobin (A1C) test. This blood test indicates your average blood sugar level for the past two to three months. Results are interpreted as follows:
Below 5.7% is normal.
5.7% to 6.4% is diagnosed as prediabetes.
6.5% or higher on two separate tests indicates diabetes.
If the A1C test isn’t available, or if you have certain conditions that interfere with an A1C test, your health care provider may use the following tests to diagnose diabetes:
Random blood sugar test. Blood sugar values are expressed in milligrams of sugar per deciliter (mg/dL) or millimoles of sugar per liter (mmol/L) of blood. Regardless of when you last ate, a level of 200 mg/dL (11.1 mmol/L) or higher suggests diabetes, especially if you also have symptoms of diabetes, such as frequent urination and extreme thirst.
Fasting blood sugar test. A blood sample is taken after you haven’t eaten overnight. Results are interpreted as follows:
Less than 100 mg/dL (5.6 mmol/L) is considered healthy.
100 to 125 mg/dL (5.6 to 6.9 mmol/L) is diagnosed as prediabetes.
126 mg/dL (7 mmol/L) or higher on two separate tests is diagnosed as diabetes.
Oral glucose tolerance test. This test is less commonly used than the others, except during pregnancy. You’ll need to not eat for a certain amount of time and then drink a sugary liquid at your health care provider’s office. Blood sugar levels then are tested periodically for two hours. Results are interpreted as follows:
Less than 140 mg/dL (7.8 mmol/L) after two hours is considered healthy.
140 to 199 mg/dL (7.8 mmol/L and 11.0 mmol/L) is diagnosed as prediabetes.
200 mg/dL (11.1 mmol/L) or higher after two hours suggests diabetes.
thanks bud.
What, under 100 when waking? No, that’s good.
Right before waking, the human body adds sugar to the bloodstream to enable you to get up. This is called the dawn phenomenon.
I think anything between 80-120 is good.
I don’t get the “Pre-diabetes” designation. You either have diabetes or you don’t. The better number is fasting blood sugar. If your fasting BS is closer to 120 (or higher) then you may be a diabetic.
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