Flavonoid supplement shown to reduce swelling after total knee arthroplasty

Medical Xpress / Wolters Kluwer Health / Journal of Bone and Joint Surgery ^ | Dec. 19, 2023 | Qiuru Wang et al

[ConservativeMind]

For patients undergoing total knee arthroplasty (TKA), treatment with diosmin—a flavonoid supplement derived from citrus fruits—reduced swelling of the knee and leg and some measures of associated pain can be achieved, reports a clinical trial.

Swelling is a common problem in patients undergoing TKA, and one that contributes to pain and patient dissatisfaction. Currently, there are no effective medication choices to reduce swelling after TKA.

Diosmin—often in combination with a related flavonoid called hesperidin—has been used to reduce swelling of the limbs in patients with venous disorders.

The exploratory study included 330 patients undergoing TKA at 13 university-affiliated hospitals. Patients were randomly assigned to either a treatment group, receiving a 14-day course of diosmin starting postoperative day 1; or to a control group, receiving no study treatment. Both groups received standard pain medications.

Swelling at specific locations was measured at 1, 2, 3, and 14 days postoperatively and compared between the diosmin and control groups. Pain scores, knee function, complication rates, and blood levels of certain inflammatory markers (C-reactive protein and interleukin-6) were also assessed.

The results showed reduced swelling at the knee, calf, and thigh up to 14 days after TKA in patients assigned to diosmin. The reduction in swelling was associated with lower pain scores on knee movement. In contrast, pain scores at rest were not significantly different for the diosmin versus control groups. Assessments of knee function recovery and levels of inflammatory biomarkers were similar as well.

Short-term complication rates were also similar between groups, supporting the safety of diosmin. There was a trend toward decreased rates of postoperative nausea and vomiting with diosmin, although the difference was not significant.

The study provides preliminary evidence that diosmin is a safe and effective treatment to reduce swelling and pain with movement after TKA.

[ConservativeMind]

Diosmin and hesperidin are available from a variety of companies, including Swanson Vitamins.

[ConservativeMind]

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[PGalt]

Thanks for posting.