Posted on 03/20/2024 6:30:21 PM PDT by ConservativeMind
In the first clinical trial of a targeted pharmacologic therapeutic for mild traumatic brain injury in pediatric patients, scientists have found preliminary evidence that adolescents and young adults with concussion who take a specific formulation of branched-chain amino acid (BCAA) supplements after injury experience faster symptom reduction and return to physical activity.
Animal model studies of mild to moderate traumatic brain injury, which has been led by Akiva S. Cohen, Ph.D., have shown that supplementation with a specific formulation of three BCAAs—leucine, isoleucine, and valine—improve neurocognitive function.
The scientists conducted a pilot, double-blind, randomized controlled trial of participants between the ages of 12-30 years who presented with concussion to outpatient clinics, urgent care, and emergency departments across the CHOP Network between June 2014 and December 2020.
Individual participants were divided into five groups consisting of a placebo arm and different treatment arms of 15 g, 30 g, 45 g, and 54 g doses of a specific formulation of BCAAs. The participants were followed for a period of 21 days after enrollment.
The study found that there was a significant reduction in and faster resolution of the total symptom score in a dose-dependent fashion with the specific formulation of BCAA supplementation, with a significant decrease in total symptoms across the study; for every 500 g of the treatment consumed, the total symptom score, on a scale of 0-54 (with 0 representing no symptoms), dropped 4 points.
Similar significant improvements were seen in a faster return to physical activity, with an increase of 0.5 on a 0-5 scale of physical activity for each 500 g of the defined BCAA supplement consumed. The treatment was very well tolerated; no serious adverse events were reported in the study, and there were no differences in mild adverse events between the placebo and treatment groups.
(Excerpt) Read more at medicalxpress.com ...
“Leucine, isoleucine, and valine”
If you’re looking for supplements containing them, you’ll be glad to know that these are easily found in online stores.
OK. Dr. Robert Malone had me convinced to start up with Creatine. Pursuant to this article, I looked up bet best supplement and it was another powder, Thorne Amino complex. For general strength and weight loss, which would you recommend that I start with? You can buy both together, but that’ an awful lot of powder!
Do you have a concussion?
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