Posted on 04/13/2024 10:09:26 PM PDT by ConservativeMind
Findings from researchers show high blood levels of TMAO (trimethylamine N-oxide) predict future risk of developing chronic kidney disease over time.
The findings build on more than a decade of research related to the gut microbiome's role in cardiovascular health and disease, including the adverse effects of TMAO, a byproduct formed by the gut bacteria from nutrients abundant in red meat, eggs and other animal source foods.
The large-scale study measured blood levels of TMAO over time in two large NIH populations and followed the kidney function of more than 10,000 U.S. adults with normal kidney function at baseline over an average follow-up period of 10 years. The investigators found that participants with elevated TMAO blood levels were at increased risk for future development of chronic kidney disease.
Higher TMAO levels were also associated with a faster rate of declining kidney function in people with normal or impaired kidney function at baseline. These associations were independent of sociodemographic characteristics, lifestyle habits, diet and other known risk factors for kidney disease. The findings also are consistent with earlier reported preclinical model studies showing TMAO directly fosters both kidney functional decline and tissue fibrosis.
Chronic kidney disease is a major and growing public health challenge in both the U.S. and globally, affecting about 10–15% of the population worldwide. It also is a strong risk factor for cardiovascular disease. The study showed that TMAO levels were as strong or even stronger an indicator of chronic kidney disease risk than the well-known risk factors such as diabetes, hypertension, advancing age and race.
The study results reinforce the growing body of evidence indicating that lowering TMAO could be an effective treatment in patients at risk for, or with early signs of, kidney disease.
"TMAO levels are highly modifiable by both lifestyle-like diet and pharmacologic interventions."
(Excerpt) Read more at medicalxpress.com ...
However, this is a big deal and we need to give thought to mitigation approaches, which I’ll post on, next.
In sum, things that reduce TMAO: Vegetarian diets, Mediterranean Diet, B vitamins, Vitamin D, pistachios, Brussels sprouts, soluble fiber, resveratrol, red wine, balsamic vinegar, cold-pressed extra virgin olive oil, and grapeseed oil.
TMAO: Why It Increases & Factors That May Reduce TMAO levels
That word should have been, “mitigations.”
I’m phone typing.
Personally I don’t trust any of these studies or whatever they are. Notice how this is right in line with global elite wanting people to not eat meat. We already know that the medical field does what ever they are told to do. Even there funding depends on it. So why should I trust them.
How old are you and well off are your kidneys?
How old are you and how long do you want to live?
I’d like to live a long life and my kidneys are functioning very well for my middle age years. My creatinine levels are average for late 20-somethings.
I will say I eat the meats described as bad, but I eat a lot more low carb veggies and I have had most of the mitigating items for decades, which might be partly why my eGFR levels are so good.
I will be 73 years old before the year is out.
I eat what I want and I drink what I want.
Life is not about living long, it is about living well.
Maybe I will make it to 80 and Maybe not.
Mom made it to 95 and was miserable for her last 15 years.
I found this article:
“What Is TMAO and How Can We Reduce Our Levels?”
By Michael Greger M.D. FACLM
March 2, 2021 Last updated: June 21, 2022
https://nutritionfacts.org/blog/how-to-reduce-your-tmao-levels/
“I don’t trust any of these studies or whatever they are. Notice how this is right in line with global elite wanting people to not eat meat.”
Yeah. When I see “NIH”, I see Fauci, masks, vaccines (I see dead people), and lean toward discounting everything. That, added to what you said about elite and red meat ... Pffft!
.
LOL! I like that one. I would like it if he offered more help.
I eat at least two eggs and have some Canadian bacon each day, and I actually have had times I took choline powder. We do eat chicken a lot, and eat salmon, beef, pork, and other seafood less, but always have animal-sourced protein each meal.
However, we do eat low carb veggies, which definitely leads us to have more cruciferous vegetables over all others. We like Brussels sprouts, broccoli, and cauliflower—a lot. We eat salads with cheese, chicken, and olive oil probably twice a week for an entire meal. We have been getting more fiber than we previously had, in the past two years. Keto friendly breads/bagels now taste decent (you have to try them all to find the good ones for you). We have always supplements B and D vitamins. We have had some balsamic vinegar multiple times a week, for many years (but just a splash). These are apparently things that accidentally help cut TMAO—and might have been helping us, for a very long time.
A lot of people might be getting additional “accidental” help by the foods they also concurrently eat. For instance, other foods with resveratrol are listed in the following article, and further includes chocolate, about all grape-based items, all peanut-based items, strawberries, blueberries, and more:
https://superfoodly.com/resveratrol-foods-supplements/
This is where it begins to look like just a modicum of a balanced diet with these items can make the whole TMOA issue pretty much moot.
There is hope in just a slight shift in eat habits. A lot of us seem to be “self medicating” and making problems like TMAO go away.
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