The only groups Trump is alienating are those groups that would never vote for him, or pretty much any other Republican, in the first place. These include:
Liberal Arts graduates who live in upper middle class neighborhoods, listen to NPR every morning, shop at the neighborhood organic food store or coop, and who have essentially zero contact with or knowledge about the ‘downtrodden’ they theoretically and abstractly support.
Academics
Lawyers - who know that the Democrats will never mess with attorneys the way they have gone after physicians and others associated with medicine.
Socialists/Marxists
The Pro-abortion crowd
The Pro-reparations crowd
The Pro-CAIR crowd.
Those feminists who actually hate men.
FU Rat,