West Virginia is a prime opportunity to go Republican, as Manchin is up for reelection, and West Virginia has becoming increasingly Republican in recent years.
Arizona can be a good opportunity. Is Kristen Sinema running for reelection as an independent, not a Democrat? If so, there could be splits in the Democrat/liberal leaning voters between Sinema and the Democrat nominee, which should help the Republican candidate.
I think Joe Manchin is going to retire.