Destruction of the Jewish Temple (70AD) did not destroy Judaism but gave Jews a lot to think about ever since. 80% chance that taking out Mecca, Medina and other Islamic holy cities will tame Islam or smash it entirely. 20% chance that Islam will have the will or ability to pursue vengeance against the destroyers of Mecca/Medina.
Islam places much more weight to the importance of holy sites, and holy cities. They have obeyed Allah so have destroyed so many churches and synagogues and built right on the ruins. One must think the opposite is true, their holiest sites get nuked, they lose the will to follow Allah. That mad Mo' the child molester and Allah were not powerful enough to protect the holiest cities of Allah.
Islam thinks it can't be "reached" and is free to commit terrorism without serious reprisal. That haveing a UN cheeroing section menas theye are in the right Islam is dead wrong. They f with America or Israel the wrong way and Mecca will be gone.