Wrong bucko, a 12 gauge shotgun loaded with 3 1/2" 00 buck is better in my opinion. Not against handguns but for home defense the shotgun is better in my opinion.
For deterence and scaring an intruder off, the sound of a shotgun is certainly the best. However, I'd be a little leery of shooting buckshot in the house, especially if you have other people (such as a wife, kids) or pets around.