Depends on your aim and the shotgun. Also depends on how worked up you are at the time.
My shotgun has been converted to "home defense/crowd control mode". It has the shortest legal barrel, plug removed so it holds the maximum number of shells, pistol grip instead of the stock for my right hand, pistol grip on the slide for my left hand, and a six shell holder attached to the side for six more rounds at the ready.
I figure I can hit and disable somebody at just about any distance I'm going to encounter within my house....