They would notice unless you emulated the need to wind it, and emulated all the tempermental aspects of a weight driven clock.
More importantly, they would notice if those eccentric aspects of the original clock were somehow important.
Neurons are not like transistors that merely switch. They are electrochemical, and their switching behavior is profoundly dependent on a zillion chemical receptors that simultaneously modify their trigger level. This is all part of the "computation". You can assert that this can be emulated, but I remain unconvinced.
In addition to switching, neurons grow new connections with their neighbors and retreat from others. Connections are strengthened or weakened by whatever happens in learning. In short, we don't know much about what they do, much less how they do it.