I work from home a lot. I analyze acquisitions for a major Canadian company. I vet the acquisitions, prepare merger models, research the industries of the target, and figure out how to structure the transactions. I also do other valuation work for some other clients, such as valuing the stock options of a small privately-held software company. I love working for myself. But make sure you don't eat too much from the kitchen! And if your employer doesn't withhold, set aside money right away. Otherwise, you'll be sorry come April 15th.
Whenever I cut myself a check from the business, the next entry is a "tax dummy" for the amount that will be due to Fed and State for that check. That way, the payment disappears from the checkbook balance and the money is there when it's time to pay the quarterly.