Yes... and for that matter, no "Sealed Vaccuum" in any Laboratory in the physical Universe is truly a "completely closed system".
So what?
Re-deploy 4 divisions of Regular Army and National Guardsmen home (from "Allies" who don't want them anyway) and station them along the Borders... and spend on Border Control and Port Inspection even half of the $90 Billion we're gonna spend "rebuilding Iraq" (a country which can rebuild itself -- by selling me gasoline!!)...
And our Ports and Borders will be as water-tight as a Duck's butt.
But it's close enough for the Duck.
best, OP
More info. to add to your list.