Posted on 10/01/2004 10:14:28 PM PDT by neverdem
There's still Bextra and, if they don't have an allergy to sulfa drugs, Celebrex.
There are some folks who do NOT respond to Bextra, celexa, or anything other than Vioxx. These people are now royally scr*wed by the Trial Lawyer Industry.
celexa = celebrex
I take it as well to forstall a total knee replacement. I am pain free. I'll take the risk as Pfizer says their long-term studies show it's safe.
Liver toxicity or hepatotoxicity is mentioned in a handy pocket reference for almost all NSAIDs except aspirin and ibuprofen. The COX-2 inhibitors have increased ALT/AST mentioned. Those are enzymes found mostly in the liver. When they're elevated because of an adverse drug reaction, it's due to hepatotoxicity, i.e. chemical hepatitis.
Here's PubMed. Try naproxen AND hepatotoxicity. Capitalize the AND. Then try the different COX-2 inhibitors instead of naproxen. You can expand a search by using (trade name OR generic name) such as (Vioxx OR rofecoxib) AND (hepatotoxicity OR hepatitis), or whatever diagnosis. Some search engines like PubMed use AND, OR and NOT as Boolean operators to expand or restrict the search. Check off articles with abstracts.
I'd like on your list, please. Vioxx....the doctors insist I keep taking it.....I've gotten a new doctor. My health has been damaged more from the "cures" than anything else.
You just get to bleed out from an Ulcer. Oh joy!
Personally I would prefer to take the risk of a heart attack to living in pain every day. But thanks to this bunch that choice has been taken away.
Why not just inform me of the risks and let me choose?
I Took Vioxx and my body swelled up like a toad and my blood
pressure went out of control. But it cured the pain. Told
the doctor and he took me off it immediately and put me on
Celebrex which works pretty well. He did warn me that with
Vioxx and Celebrex there is a remote danger of internal bleeding and if that happens that I was to drop everything and call 911.
Topol relishes wallowing the "I Told You So" afterglow while millions of arthritis sufferers have had a very effective medication withdrawn.
While I have no doubt there may be a few patients who have died while on Vioxx therapy one has to temper that notion with the understanding of the increased risk of cardiovascular complications caused by even the most tolerated and ubiquitous medications.
If you think for one moment that people have not died from taking ibuprofen and naproxen and othe NSAIDs, you are crazy.
My suspicion is that there is more to Topol's indignation than seen at the surface. Clinical studies often create strange bedfellows and bruised egos. I would fully anticipate Topol to attempt to assasinate Merck's pending ARCOXIA submission to further enhance his "I'm a genius and your not" attitude.
Any NSAID, including other COX-2 inhibitors can cause a GI bleed. You didn't know or understand that???? Ever hear of the terrible side effects of aspirin???
What was your original diagnosis for which VIOXX was prescribed??? Did you have other already existing cardiovascular syndromes present?? Undiagnosed diabetes??
Your story is similar to Swiss Cheese without further clarification.
All I know is that I have to take Ibuprofen 3 or 4 times a day, it does not work as well, and it gives me severe heartburn after a few days.
The naproxen is inhibits platelet function - this is not an "unproven" cardioprotective effect. It is *exactly* the reason that aspirin is used to prevent heart attacks and strokes and the reason that people on coumadin (warfarin) can take Celebrex, Bextra and (until this week) Vioxx.
This is what I call "lawyer-talk," what some people will recognize as "CYA."
I am convinced that some of the opposition to many drugs is financial: the people who are pushing universal (govenment) insurance are anti-brand, anti-once-a-day meds.
I will sign any sort of consent to continue my Bextra. (I'm sure that some would rather I take ibuprofen and Nexium, or maybe just die of a GI bleed. The latter would save a lot of money, wouldn't it?)
I was given Vioxx to take a year ago when I got out of the hospital for a pulmonary embolism. I asked the doctor "does this have any side effects?" he said "NO". I said bullshit,as I went and read up on the drug myself and that with a combination of another med I was on would most likely have driven me right back into ICU.
"One must always be deeply skeptical of the rhetoric of the NY Times, a slick propaganda outlet with little credibility and a massive agenda."
You are letting your bias interfere with your judgement. The article was written by a very respected cardiologist, with lots of facts to back up what he is saying.
I remember a hematologist telling me in the early 1990s that aspirin irreversibly inhibits platelet aggregation, as opposed to the other NSAIDs which reversibly inhibit platelet aggregation.
I vaguely remember an article that recommeded that patients with CAD taking a daily aspirin should take it one hour before any NSAIDs they take for pain for that reason.
Seems to me this article could have just as easily read, "Placebo causes heart attacks".
The New York Times is virulently devoted to the destruction of the American pharmaceutical industry. The bias of the Times is overwhelming and cannot be trusted.
Ya but they can be murder on your liver.
As an aside, I just caught the first commercial for a local law office already preparing to sue... Fluckin Lawyers should be shot.
Rumor has it that Celebrex and Bextra will soon be withdrawn from the market; VERY soon.
In less than 48 hours after the news broke about Vioxx, a local lawyer scum already had an ad in the newspaper soliciting Vioxx patients for the litigation lottery.
Dear God, I hope not. I take Bextra for the arthritis in my back (which is only a sidebar to the four herniated disks in my thoracic and cervical apine.....)
I cannot imagine returning to a morning without Bextra! It has allowed me to "uncurl" in the morning and actually function. I'm 37 years old, but I feel like I'm 92 first thing in the morning.
Sigh. I hope Bextra isn't pulled!
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