Boss Rendell will be on the ballot for Governor in 06 and his machine will be out in force. It will likely be a very close race.
By '06 Rendell isn't going to have a walk in the park for reelection. Santorum outpolled Bush in 2000 by the same margin that Gore did. I guess it all comes down to who he has as an opponent. Dems seldom put up good opposition for senate and I can't think of anyone right now that Santorum couldn't beat.