It's pretty funny considering the context: lots of urbanites consider themselves "allergic" to wheat. As in bread or anyplace wheat might lurk. (Their overpriced "nutritionalists" have diagnosed them this way.)
Humor in that the red states are where wheat is mostly produced!
To apply William Jennings Bryan's "Cross of Gold" speech at the 1896 Democratic convention in a modern context, "You come to us and tell us that the great cities are in favor of social and cultural liberalism; we reply that the great cities rest upon our broad and fertile prairies. Burn down your cities and leave our farms, and your cities will spring up again as if by magic; but destroy our farms and the grass will grow in the streets of every city in the country."