The unusual part is that lesser amounts of the chemical (Atrozine) per billion liters of water causes more damage than higher amounts. It is thought that the amphibians' immune systems detect the higher levels but effectively ignore the miniscule levels that cause the worst damage.
This program asked the disturbing question "If we've introduced 70,000 inorganic compounds to our ecosystem in the relatively short period of 60 years, and have no possible means to track how all of those compounds can interact with each other in the natural cycle, how can we know what effects this will have on plants, animals and we humans who also ingest the water these molecular compounds find their way into."
God only knows what IG Farben has unknowingly unleashed on Germany over the years.
Among other things you are talking about endocryn disrupters.
There is some nasty stuff out there and some Freepers will tell you that nothing man can do can harm the planet. These Freepers are pretty stupid and very blind.
Frogs are important to pay attention to because they are canaries in a mine shaft for all creatures.
They live in water and on land and have an anatomy not so far off from humans (which is why we disect them in high school).
Nature is an infinite sink and will eventually repair itself over time. But even an infinite sink can get full, because the drain off is not infinitely large.
See my tag line.