Oh, I hear ya on the wrist thing. I have my desk set up ergonomically with data arm supports, a raised mouse pad, a footrest and an adjustable keyboard. I also do stretching exercises many times a day.
I thought about working from home because it sounds so nice to be able to type in my PJs, but I've always gotten up and gone to work, and do not know if I'd have a very good work ethic working from home. It'd be too easy to tell myself I could go out with friends for a little bit, and do the typing later. Not to mention, my financial situation is such that I am renting a room now, and there'd be no room for the set up I would need.
That's good. My mom's computer desk doesn't have the best setup, at least for me. It probably works great for her, or I would assume so since she works at it every day.
My mom's usually pretty good about working but I have a completely different mentality so if I were really working at home and not just helping out, I'd probably get lazy. But my mom has a lot of different accounts so she couldn't work in an office even if she wanted to.